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Description
TCI D4321 2,4-Difluorophenylacetic Acid is a fluorinated arylacetic acid carrying two fluorine atoms at the 2- and 4-positions of the benzene ring. The compound belongs to the family of fluorinated building blocks, intermediates prepared specifically for introducing fluorinated aromatic motifs into target molecules. In the organic synthesis laboratory, its carboxylic acid group serves as a highly versatile entry point: it can be converted into amides, esters, acid chlorides, alcohols, ketones, and a wide range of heterocycles through cyclization reactions commonly used in medicinal chemistry.
The primary reason chemists select this compound is the influence that fluorine substitution exerts on molecular properties. Fluorine is strongly electronegative yet small in size, so its incorporation alters acidity, electron distribution, and lipophilicity without adding significant steric bulk. The 2,4-substitution pattern produces an electron-poor ring in which the ortho fluorine influences the conformation of the acetic acid side chain, while the para fluorine stabilizes the ring against oxidative metabolism. The strong C–F bond further improves the chemical stability of the resulting derivatives, and the solid form of the material makes weighing and handling straightforward.
In Indonesian laboratories, this building block is typically used in university and institutional research groups working on organic synthesis and medicinal chemistry, as well as in pharmaceutical and agrochemical research and development units. It is normally required in small to moderate quantities for exploratory route development, analogue preparation, and the assembly of fluorinated intermediates. Because it is supplied as a defined TCI catalogue item with a specific CAS identity, it is also convenient for laboratories that need traceable, consistently documented starting materials for repeated syntheses.
Laboratory Applications
- Medicinal chemistry analogue synthesis — the difluorinated aryl ring is introduced to modulate lipophilicity and metabolic stability of candidate molecules without adding steric bulk.
- Amide and ester coupling reactions — the free carboxylic acid group reacts readily under standard activation conditions to give fluorinated amides and esters for screening libraries.
- Heterocycle construction — the acetic acid side chain participates in common cyclization routes, giving access to fluorinated heterocyclic cores widely used in drug discovery programmes.
- Agrochemical research intermediates — the electron-poor, fluorine-stabilized aromatic ring is a recurring motif in agrochemical actives requiring resistance to oxidative degradation.
- Reference and route development work — as a defined catalogue compound with a fixed CAS identity, it supports reproducible synthetic route optimization and method development studies.
Specifications
- Brand: TCI
- Catalogue number: D4321
- CAS number: 81228-09-3
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Physical form: solid
- Pack sizes: available in standard TCI research-scale pack sizes; please confirm the required packaging when ordering
- Storage: keep in the tightly closed original container, in a cool, dry, well-ventilated place
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well-ventilated area, away from moisture, direct sunlight, and incompatible substances such as strong bases and strong oxidizing agents. Glass or other chemically resistant containers with secure closures are suitable for aliquots and working stocks. As a carboxylic acid, the solid may be irritating to skin, eyes, and the respiratory tract, so weighing and transfer should be carried out in a fume hood using safety glasses, gloves, and a laboratory coat. Avoid generating or inhaling dust, close the container immediately after use to limit moisture uptake, and clean up spills promptly. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.
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