Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Description
TCI D3637 3,5-Dichloro-2,4-difluoroaniline is an aromatic aniline that carries two chlorine atoms and two fluorine atoms at fixed, defined positions around the amine group. The compound is classified as a fluorinated building block, and its role in the laboratory is to supply a densely halogenated benzene core that is ready for further functionalisation. A four-halogen substitution pattern of this kind is almost impossible to construct selectively through direct halogenation in an ordinary laboratory, so having the compound available as a starting material sharply reduces the number of synthetic steps required and the risk of failure along a long route.
The property that makes this compound the preferred choice is the electron-poor aromatic ring created by four halogen substituents acting together. This condition activates the fluorine atoms toward nucleophilic aromatic substitution, so particular positions can be replaced by amines or alkoxides in a directed manner, while the chlorine atoms tend to remain in place and can be exploited later in metal-catalysed cross-coupling steps. The primary amine group itself serves as an entry point for acylation, diazotisation, and heterocyclic ring formation. A framework of this type is characteristic of fluorinated bioactive scaffolds, which is why the material is valued where a predictable substitution sequence matters more than raw reactivity.
In Indonesian laboratories, this building block is typically drawn on in university and institutional research groups working on multi-step organic synthesis, medicinal-chemistry exploration, and fluorinated intermediate development. Because the halogen pattern arrives pre-installed, small research groups that lack specialised halogenation facilities can still reach advanced targets. It is normally ordered in small research quantities for method development, route scouting, and the preparation of reference compounds rather than for production-scale work.
Laboratory Applications
- Nucleophilic aromatic substitution studies: the electron-poor ring activates the fluorine positions, allowing amines or alkoxides to be introduced in a controlled, position-selective manner during route development.
- Metal-catalysed cross-coupling chemistry: the chlorine atoms survive earlier substitution steps and remain available as handles for palladium- or nickel-catalysed carbon–carbon and carbon–nitrogen bond formation.
- Heterocycle construction: the primary aromatic amine acts as a reliable entry point for cyclisation reactions that build fused nitrogen-containing rings on a halogenated benzene core.
- Fluorinated intermediate synthesis: the pre-installed four-halogen pattern removes several difficult selective halogenation steps, shortening synthetic sequences and lowering the failure risk of long routes.
- Diazotisation and acylation work: the free amine can be diazotised or acylated to generate amides, azo derivatives, and other functionalised products from a single common precursor.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 83121-15-7
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: D3637
- Pack sizes: available in research-scale laboratory pack sizes; please confirm the currently listed packaging option when ordering
- Storage note: keep in the tightly closed original container, protected from light and moisture, in a cool and well-ventilated place
Handling and Storage
Store the material in its tightly closed original container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and moisture. Amber glass or the manufacturer's supplied packaging is suitable; keep the container clearly labelled and separated from strong oxidising agents and strong bases. Handle the compound in a fume hood, wearing safety glasses, nitrile gloves, and a laboratory coat, and avoid inhalation of dust and any contact with skin or eyes. Weigh out only the amount needed, reseal promptly to limit exposure to air and humidity, and collect halogenated organic residues as designated chemical waste. Always consult the manufacturer's safety data sheet before first use.
Sold out
