2,4-Dibromothiazole TCI D3667

Name: TCI D3667 4175-77-3 2,4-Dibromothiazole
Brand: TCI
SKU: TCI2510D366724014
Price: 768600.0 IDR
Availability: InStock

Rp 768.600,00

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Berat 1g 5g 25g

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Description

TCI D3667 2,4-Dibromothiazole is a heterocyclic building block based on a thiazole core carrying two bromine atoms at the 2- and 4-positions. The thiazole ring is a scaffold encountered very frequently in drug molecules, agricultural active ingredients, and functional materials, which makes this compound a high-value starting point in organic synthesis. Its main role in the laboratory is that of a versatile starting material: the two bromine groups act as reactive "handles" that can be exchanged for carbon–carbon or carbon–heteroatom bonds through metal-catalysed coupling reactions or nucleophilic substitution, allowing the thiazole framework to be developed into a wide range of derivatives in a directed manner.

The property that makes this compound a preferred choice is the difference in reactivity between the 2-position and the 4-position of the thiazole ring. The 2-position is more electrophilic because it sits adjacent to both the nitrogen and the sulfur atom, so it commonly reacts first, while the 4-position can be functionalised in a subsequent step. This difference enables stepwise synthetic strategies for obtaining unsymmetrically substituted thiazole derivatives without the need for long protecting-group routes. In practice, this means fewer synthetic steps, more predictable regiochemistry, and cleaner intermediates for researchers building complex heterocyclic targets from a single, well-defined precursor.

In Indonesian laboratories, this material is typically used in university research groups, government research institutes, and industrial R&D units working on medicinal chemistry, agrochemical discovery, and functional materials. It is generally applied at the bench scale, where a small quantity of a well-characterised building block supports a full series of derivative syntheses. Because it is supplied by TCI as a catalogue building block, it fits naturally into method-development work, thesis and postgraduate research, and early-stage screening programmes that require reliable, reproducible starting materials.

Laboratory Applications

Palladium-catalysed cross-coupling chemistry — both bromine substituents serve as leaving groups for Suzuki, Stille, Sonogashira, and Negishi couplings, giving direct access to arylated and alkynylated thiazole derivatives.
Medicinal chemistry scaffold construction — the thiazole ring is a common motif in drug molecules, so this dibrominated precursor lets researchers assemble focused derivative libraries around a proven pharmacophore.
Sequential regioselective functionalisation — the greater electrophilicity of the 2-position allows chemists to react one site first and the 4-position later, producing unsymmetrically substituted thiazoles in a controlled order.
Agrochemical active-ingredient research — thiazole frameworks appear widely in agricultural actives, making this building block useful for preparing and screening candidate structures during discovery-stage synthesis work.
Functional materials synthesis — the ring is used in functional material design, and the two bromine handles permit extension into conjugated or heteroatom-linked systems required for materials chemistry studies.

Specifications

Brand: TCI
Product code: D3667
CAS number: 4175-77-3
Chemical name: 2,4-Dibromothiazole
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in TCI catalogue research pack sizes; please confirm the required quantity when ordering
Storage: store according to the manufacturer's stated conditions on the product label and safety data sheet

Handling and Storage

Store the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials, following the storage conditions stated by the manufacturer on the product label and safety data sheet. Keep the compound in its original supplier container, or in a chemically compatible, clearly labelled glass container with a secure closure. Handle inside a fume hood using standard laboratory personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat. Avoid inhalation of dust or vapour and avoid contact with skin and eyes. Consult the current safety data sheet before use, and dispose of residues and contaminated materials in accordance with applicable chemical waste regulations.