• 1,3-Dimethoxy-1,3-dimethylurea (CAS 123707-26-6) - TCI D3990 - AMI Scientific
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CAS 123707-26-6

1,3-Dimethoxy-1,3-dimethylurea TCI D3990

1,3-Dimethoxy-1,3-dimethylurea TCI D3990
Rp 5.106.150,00
Rp 5.106.150,00
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TCI D3990 1,3-Dimethoxy-1,3-dimethylurea (CAS 123707-26-6) is a doubly substituted urea derivative that carries two N-methoxy-N-methyl groups on either side of its central carbonyl. This architecture positions the compound both as a non-heterocyclic building block and as a bifunctional acylating reagent in the organic synthesis laboratory. The N-methoxy-N-methyl amide pattern, widely recognised as the Weinreb motif, makes the material attractive as a carbonyl source that can be delivered to organometallic reagents in a controlled fashion, allowing researchers to obtain ketone or amide products without the double-addition side reactions that commonly interfere with such transformations.

The principal advantage of this reagent lies in reactivity control. The nitrogen atoms bearing methoxy groups are able to stabilise a chelated metal alkoxide intermediate after the first nucleophilic attack, so addition of a second nucleophile is held back until the acidic work-up stage is performed. The molecular symmetry of the compound also provides flexibility: both sides of the carbonyl can be functionalised in stages, enabling the construction of unsymmetrical ketones as well as directed amides. It is furthermore a practical reagent to handle, being stable under normal storage conditions and requiring no hazardous activation step before use.

In Indonesian laboratories, this material is typically used in university and institutional synthetic chemistry groups, as well as in research and development units working on fine chemicals and pharmaceutical intermediates. Because it behaves predictably and needs no special activation procedure, it fits well into laboratories where handling infrastructure is shared between several projects. Researchers preparing ketone and amide targets on a bench or small pilot scale generally value a carbonyl donor whose reaction course can be stopped and controlled at a defined stage.

  • Controlled ketone synthesis: the Weinreb-type N-methoxy-N-methyl pattern releases the carbonyl to organometallic reagents in a single, controlled addition step, avoiding the over-addition that plagues conventional acylating agents.
  • Directed amide preparation: the substituted urea framework acts as a carbonyl donor towards amine nucleophiles, giving researchers a defined route to targeted amide products without uncontrolled multiple substitution.
  • Unsymmetrical carbonyl construction: because the molecule is symmetrical about the carbonyl, both sides can be functionalised sequentially, allowing stepwise assembly of unsymmetrical ketones from two different nucleophile partners.
  • Non-heterocyclic building block work: the compound serves as a compact, non-heterocyclic scaffold for organic synthesis programmes that require a stable urea-based intermediate rather than a ring-containing precursor.
  • Fine chemical and intermediate research: the reagent suits development laboratories preparing pharmaceutical and fine chemical intermediates, since it is bench-stable and needs no hazardous pre-activation before entering a synthetic sequence.

Brand TCI (Tokyo Chemical Industry)
CAS number 123707-26-6
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes available in standard TCI research and laboratory pack sizes; please confirm the currently listed packaging option when ordering
Physical form —
Storage stable under normal laboratory storage conditions
  • Catalogue number: D3990
  • Chemical name: 1,3-Dimethoxy-1,3-dimethylurea

Store the container tightly closed in a cool, dry and well-ventilated chemical store, away from heat sources, direct sunlight and incompatible reagents. Keep the material in its original manufacturer container or in a clean, chemically resistant and clearly labelled vessel, and reseal it promptly after each withdrawal to limit exposure to atmospheric moisture. Handle the compound in a fume hood using a laboratory coat, safety glasses and suitable chemical-resistant gloves, and use dry glassware and clean spatulas when weighing out portions. Avoid generating dust, wash hands after handling, and always consult the manufacturer's safety data sheet before beginning work.

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