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Description
TCI D4133 3,5-Dichloro-2,6-dimethoxybenzoic Acid is a non-heterocyclic building block based on a benzoic acid core that carries a fairly distinctive substitution pattern: two chlorine atoms at the 3 and 5 positions and two methoxy groups at the 2 and 6 positions. In the laboratory, this compound serves as an intermediate for constructing densely functionalized aromatic frameworks, so researchers do not have to carry out their own sequence of halogenation and etherification steps. This role matters in medicinal chemistry, agrochemical research, and the development of marker compounds, because it saves synthetic stages while helping to preserve reproducibility of results.
The characteristic that makes this compound attractive is the combination of electron-withdrawing and electron-donating groups on a single ring. The chlorine atoms are electron-withdrawing and can also act as reaction points in suitable cross-coupling chemistry, while the methoxy groups push electron density toward the ring and lock in the steric environment around the carboxylate. The positioning of the two methoxy groups flanking the carboxylic acid gives the framework a symmetric arrangement, which makes spectra easier to interpret and helps direct the conformation of derivative products. The carboxylic acid group itself provides a straightforward handle for amidation, esterification, and salt formation.
In Indonesian laboratories, a building block of this type is typically used in university research groups, government research institutes, and industrial R&D units working on organic synthesis. Because it arrives as a ready-made, pre-functionalized aromatic scaffold, it fits well in settings where instrument time, reagent budgets, and fume hood capacity are shared across several projects. It is commonly held as a stock item on the synthesis shelf and drawn on for exploratory route-scouting work, method development, and the preparation of reference materials.
Laboratory Applications
- Medicinal chemistry scaffold preparation — the pre-installed chlorine and methoxy substituents let researchers move directly to analogue elaboration instead of spending steps building the substituted aromatic core themselves.
- Agrochemical research intermediates — the dichlorinated, dimethoxylated benzoic acid framework is a recognised structural motif in this field, giving a practical starting point for exploring new active-structure candidates.
- Marker and reference compound synthesis — the symmetric substitution pattern gives clean, readily interpreted spectra, which is valuable when preparing well-characterised standards for analytical comparison work.
- Cross-coupling route development — the chlorine positions can serve as reaction points in suitable coupling chemistry, allowing chemists to extend the aromatic ring toward more complex targets.
- Amide and ester library preparation — the free carboxylic acid group offers a direct handle for amidation, esterification, and salt formation across a series of derivatives from one common intermediate.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 73219-91-7
- Catalogue Code: D4133
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack Sizes: available in standard research-scale packaging; please confirm the currently offered pack options when ordering
- Storage: store in a cool, dry place in a tightly closed container, following the manufacturer's product documentation
Handling and Storage
Store this material in a tightly closed original container in a cool, dry, well-ventilated area, away from direct sunlight, moisture, and incompatible chemicals. Keep it segregated from strong bases and strong oxidising agents, and always refer to the manufacturer's Safety Data Sheet and product label for the specific storage conditions stated for this item. Handle the solid inside a fume hood or with adequate local exhaust ventilation to avoid generating and inhaling dust. Wear standard personal protective equipment, including safety goggles, chemical-resistant gloves, and a laboratory coat. Use clean, dry spatulas and glassware when weighing and transferring, and reseal the container promptly after use to limit moisture uptake and contamination. Dispose of residues and contaminated materials through the laboratory's designated chemical waste stream.
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