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Description
TCI D4282, with CAS number 1558-17-4, is 4,6-Dimethylpyrimidine, a simple heterocyclic compound consisting of a pyrimidine ring bearing methyl groups at the 4 and 6 positions. Pyrimidine is one of the most important heterocyclic cores in chemistry, since it forms the basic framework of the nucleic acid bases as well as of many biologically active molecules. As a heterocyclic building block, this compound gives researchers a ready-made nitrogen-containing ring system, so there is no need to construct the ring from scratch and the work can be directed immediately toward further functionalisation.
The property that makes this compound a preferred choice is the electronic character of the pyrimidine ring, which is electron-poor because of the two nitrogen atoms at positions 1 and 3. This condition makes the ring inclined to react with nucleophiles while remaining relatively resistant to electrophilic substitution. The two methyl groups at positions 4 and 6 are also not merely passive substituents: the protons on a methyl group adjacent to a ring nitrogen are sufficiently acidic that they can be deprotonated and then reacted with electrophiles to extend the side chain. In addition, the ring nitrogen atoms can act as a weak base or as a coordination site for metal ions.
In Indonesian laboratories, a building block of this kind is normally used in university and institutional research groups as well as in industrial R&D units that carry out synthetic work. It is typically drawn upon when a nitrogen heterocycle is needed as the starting point of a synthetic route, whether for the preparation of derivatives, for method development, or for exploratory reaction studies, and is stored as part of the standard collection of heterocyclic starting materials.
Laboratory Applications
- Heterocyclic synthesis starting material: provides a pre-formed pyrimidine ring so that a synthetic route can begin from an intact nitrogen heterocycle rather than requiring ring construction.
- Side-chain elaboration through deprotonation: the acidic methyl protons adjacent to ring nitrogen can be deprotonated and reacted with electrophiles to build extended side chains from the ring.
- Nucleophilic substitution studies: the electron-poor pyrimidine ring reacts readily with nucleophiles, making the compound useful for investigating and applying substitution chemistry on nitrogen heterocycles.
- Coordination chemistry and metal complexation work: the ring nitrogen atoms can serve as coordination sites for metal ions, allowing the compound to act as a nitrogen donor ligand.
- Preparation of derivatives for bioactive molecule research: because pyrimidine is the core of the nucleic acid bases and many active molecules, this building block supports derivative synthesis programmes.
Specifications
- Brand: TCI
- CAS Number: 1558-17-4
- Chemical name: 4,6-Dimethylpyrimidine
- Product code: D4282
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack sizes: available in the standard research pack sizes offered by TCI for this catalogue item; please refer to the current catalogue listing for the options available.
- Storage: store according to the conditions stated on the manufacturer's label and Safety Data Sheet.
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, away from heat, ignition sources, and incompatible chemicals, and follow the specific storage conditions stated on the manufacturer's label and Safety Data Sheet for this product. Keep the material in its original supplier container, or in a chemically compatible and clearly labelled alternative, and close it firmly after every use to limit exposure to air and moisture. Handle the compound in a fume hood using appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Avoid inhalation of vapours and contact with skin and eyes, keep containers away from open flames, and consult the Safety Data Sheet before use and before any disposal of residues.
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