Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Couldn't load pickup availability
Description
TCI E0767 4-Ethylphenyl Isocyanate is an aromatic reagent that carries a highly reactive isocyanate group on a benzene ring bearing an ethyl substituent at the para position. As a member of the aryl isocyanate family, this compound plays an important role in the laboratory as a reagent for forming urea and carbamate linkages. Researchers use it to anchor the 4-ethylphenyl fragment onto molecules containing amine or hydroxyl groups, whether in small-molecule synthesis, in the derivatisation of analytes for analytical purposes, or in the surface modification of materials and polymers.
The property that makes this reagent valuable is the reactivity of the isocyanate group towards nucleophiles bearing active hydrogen. Reaction with primary or secondary amines proceeds rapidly and yields substituted ureas without the need for additional coupling reagents, while reaction with alcohols gives carbamates. Because these reactions generally proceed cleanly and without salt by-products, the purification stage becomes considerably simpler. The ethyl substituent at the para position imparts moderate lipophilicity and also makes signal assignment easier in spectroscopic analysis, so the reagent is likewise used as a tag in chromatographic derivatisation.
In Indonesian laboratories, TCI E0767 is typically found in synthetic organic chemistry groups at universities and research institutes, as well as in analytical and materials laboratories. It is used where a defined aryl fragment must be attached to amine- or hydroxyl-bearing substrates under straightforward conditions, and where a derivatisation reagent is needed to make analytes easier to detect and identify. Its convenience in avoiding extra coupling reagents suits laboratories that work with modest quantities and prefer simple work-up procedures.
Laboratory Applications
Urea synthesis from amines — reaction with primary or secondary amines proceeds rapidly to give substituted ureas without requiring any additional coupling reagent or activator.
Carbamate formation from alcohols — hydroxyl-containing substrates react with the isocyanate group to yield carbamates, providing a direct route to protected or functionalised alcohol derivatives.
Building-block chemistry for small molecules — the reagent installs a defined 4-ethylphenyl fragment onto a target scaffold, making it useful in non-heterocyclic building-block strategies.
Analytical derivatisation for chromatography — the ethyl-substituted aromatic tag improves analyte detectability and recognition, so the reagent serves as a labelling agent in chromatographic workflows.
Surface and polymer modification — active-hydrogen groups on material or polymer surfaces react with the isocyanate function, allowing the aryl fragment to be grafted onto the substrate.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 23138-50-3
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Product code: E0767
Pack sizes: available in standard TCI research-scale packaging; please confirm the currently offered pack size when ordering.
Storage: keep tightly closed under dry conditions, protected from moisture.
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, away from moisture, since isocyanates react readily with water and with other active-hydrogen compounds. Keep the material in its original tightly sealed container, or in a clean glass vessel with a moisture-resistant closure, and consider storing under an inert atmosphere where a laboratory's practice calls for it. Handle in a fume hood using gloves, safety glasses, and a laboratory coat, as isocyanates are irritants and potential sensitisers. Keep away from amines, alcohols, and other incompatible reagents during storage. Allow closed containers to reach room temperature before opening to limit moisture condensation, and always consult the manufacturer's safety data sheet before use.
