TCI F0623 2-Fluoro-6-nitrophenol is a substituted phenol carrying a fluoro group at one ortho position and a nitro group at the other ortho position relative to the aromatic hydroxyl. In organic synthesis laboratories, this material serves as a fluorinated building block: a small starting material that already carries a defined substitution pattern, so chemists do not have to construct that arrangement from scratch. The combination of three functional groups on a single benzene ring makes this compound a practical point of departure for assembling heterocyclic frameworks, aminophenol derivatives, and more elaborate target molecules in medicinal chemistry and materials research.
The characteristics that lead chemists to select this compound lie in its electronic arrangement. The nitro group is a strong electron-withdrawing substituent and therefore activates the aromatic ring toward nucleophilic aromatic substitution, while the fluorine atom provides both a reactive site and a modulator of electronic character and lipophilicity when it is retained in the final product. The phenolic hydroxyl group supplies a handle for alkylation, acylation, and ether formation. In ortho-nitro phenols, an intramolecular hydrogen bond is generally formed, and this interaction influences the behaviour of the hydroxyl group and the overall properties of the molecule.
In Indonesian laboratories, this building block is typically used in university research groups, institutional synthesis laboratories, and industrial R&D units that prepare intermediates on a small scale. It is normally handled at the bench in a fume hood as part of multi-step synthetic routes, where a defined substitution pattern shortens the preparation sequence. Researchers working on medicinal chemistry projects and functional materials commonly order such fluorinated intermediates in small quantities suited to exploratory work.
TCI brochures (PDF)
- Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 17
- Nucleophilic aromatic substitution chemistry: the strongly electron-withdrawing nitro group activates the ring and the fluorine serves as a leaving group, giving a reliable route to displacement products.
- Heterocycle construction: the adjacent nitro and hydroxyl functionalities provide the atoms and reactivity needed to build fused ring systems without additional functional group installation steps.
- Preparation of aminophenol derivatives: reduction of the nitro substituent converts this compound into an aminophenol scaffold useful as an intermediate for further derivatisation work.
- Medicinal chemistry intermediate synthesis: the retained fluorine atom lets researchers modulate electronic character and lipophilicity in candidate molecules during structure-activity relationship studies.
- Phenol derivatisation studies: the free hydroxyl group supports alkylation, acylation, and ether formation, allowing systematic preparation of analogue series from a single common starting material.
| Brand | TCI |
|---|---|
| CAS number | 1526-17-6 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | available in standard research-scale packaging; please confirm the pack size when ordering |
| Physical form | — |
| Storage | store in a cool, dry place in a tightly closed original container |
- Chemical name: 2-Fluoro-6-nitrophenol
Store this product in its tightly closed original container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials. Amber glass or the supplier's original packaging is suitable for keeping the material protected from light and moisture. All handling should take place in a properly functioning fume hood, with nitrile gloves, safety goggles, and a laboratory coat worn at all times. Nitroaromatic and phenolic compounds require careful handling, so avoid skin contact, inhalation of dust, and the generation of aerosols. Keep containers closed when not in use, label secondary containers clearly, and dispose of waste through the laboratory's chemical waste stream. Always consult the manufacturer's Safety Data Sheet before use.
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