5-Fluorouridine TCI F0636

Name: TCI F0636 316-46-1 5-Fluorouridine
Brand: TCI
SKU: TCI2510F063630550
Price: 1270500.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI F0636 5-Fluorouridine is a pyrimidine nucleoside analogue consisting of a uracil base fluorinated at the fifth position joined to a ribose sugar. This structure places it within the family of nucleoside biochemical reagents, the materials that form the backbone of nucleic acid research. In the laboratory, nucleoside analogues of this kind serve as tools for investigating how cells process RNA, how enzymes recognise their substrates, and how small perturbations in base structure can influence an entire chain of biological events, both in growing cells and in cell-free systems.

The property that makes this compound a preferred choice is its very close resemblance to natural uridine, differing only by a single fluorine atom that replaces the hydrogen at the fifth position of the uracil ring. Fluorine is not far removed from hydrogen in size, so the compound is still recognised by a range of enzymes, yet the exceptionally strong carbon–fluorine bond fundamentally alters its chemical behaviour. For this reason the compound is known as an antimetabolite that interferes with RNA processing pathways. The fluorine atom simultaneously acts as a useful analytical marker in observations made by fluorine NMR spectroscopy.

In Indonesian laboratories, a reagent of this class is typically encountered in university research groups, biomedical and molecular biology institutes, and analytical laboratories working on nucleic acid chemistry. It is generally purchased in small research quantities and stored centrally, since work of this kind is usually carried out on an experimental scale rather than a production scale. Handling is normally assigned to trained personnel who prepare stock solutions for a defined series of experiments.

Laboratory Applications

RNA metabolism studies: the analogue can be taken up in place of natural uridine, allowing researchers to trace how cells incorporate and subsequently process ribonucleotides during transcription-related work.
Enzyme recognition and substrate specificity experiments: the near-identical geometry to uridine lets investigators test how tightly an enzyme discriminates between a natural substrate and a fluorinated mimic.
Antimetabolite research in cell culture: because the compound interferes with RNA processing pathways, it serves as a model agent for examining cellular responses to nucleoside-based metabolic disruption.
Fluorine NMR spectroscopy: the single fluorine atom provides a clean, background-free analytical marker that can be followed spectroscopically without the need for radiolabelling or fluorescent tagging.
Cell-free biochemical assays: reactions reconstituted outside the cell can use this analogue to probe individual enzymatic steps in isolation, away from the complexity of intact cellular systems.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 316-46-1
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Product code: F0636
Pack sizes: supplied in research-scale quantities; please confirm the pack sizes currently listed for this item
Storage: store as directed on the manufacturer's label and accompanying documentation

Handling and Storage

Store the container tightly closed in a cool, dry place, protected from light and moisture, and follow the storage temperature stated on the manufacturer's label and safety data sheet. Keep the material in its original supplied container, or in a chemically compatible, clearly labelled vessel if aliquoted; amber glass vials are commonly used for light-sensitive nucleoside reagents. Allow refrigerated or frozen material to reach room temperature before opening to avoid condensation. Handle in a well-ventilated area or fume hood using gloves, safety glasses, and a laboratory coat, avoid generating dust, and prepare solutions only in the quantity required. As an antimetabolite, the compound should be treated as biologically active: restrict handling to trained personnel and dispose of residues and contaminated consumables through the laboratory's chemical waste route.