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Description
TCI D3615 2'-Deoxy-2'-fluorouridine, CAS 784-71-4, is a uridine nucleoside analogue in which a fluorine atom replaces the hydroxyl group at the 2' position of the sugar ring. The compound completes the family of 2'-fluoro nucleosides that form the backbone of many modified nucleic acid designs. In the laboratory, its roles include serving as a starting material for oligonucleotide synthesis monomers, a test compound in the development of antiviral and anticancer agents, and a reference compound that supports the identification and quantification of fluorinated nucleosides in instrumental analysis.
The characteristic that makes this material sought after is the combination of structural simplicity with the substantial impact of the fluorine modification. The uracil base is neutral and carries no exocyclic amino group, so protecting-group steps during synthesis become more concise than they are for cytidine analogues. Meanwhile, the fluorine atom at the 2' position directs the sugar conformation, increases the stability of the duplexes that are formed, and strengthens the resistance of the strand to nucleic acid cleaving enzymes. Good solubility in polar solvents and a stable solid form make the material straightforward to weigh, purify further, and dissolve for use.
In Indonesian laboratories, this nucleoside is typically used in university and institutional research groups working on nucleic acid chemistry, in synthetic laboratories preparing modified oligonucleotide building blocks, and in analytical laboratories that require a defined reference substance for fluorinated nucleoside work. Its stable solid form and predictable handling behaviour suit both teaching and research settings, where material is weighed out in small portions across a series of synthetic or analytical experiments.
Laboratory Applications
Oligonucleotide monomer preparation — the neutral uracil base requires fewer protecting-group operations, making the compound a convenient starting point for phosphoramidite and related building block routes.
Antiviral compound development — as a 2'-fluoro nucleoside analogue, it serves as a test compound and synthetic intermediate in screening programmes directed at viral replication targets.
Anticancer research — the compound functions as a test material in the development of nucleoside-based agents, where 2' modification influences biological interaction and metabolic behaviour.
Modified nucleic acid duplex studies — fluorine at the 2' position directs sugar conformation and raises duplex stability, letting researchers study structure and thermal behaviour systematically.
Analytical reference work — as a defined fluorinated nucleoside, it supports identification and quantification during instrumental analysis, providing a consistent comparison point for method development.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 784-71-4
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Product code: D3615
Physical form: stable solid, soluble in polar solvents
Pack sizes: available in research-scale pack sizes; please refer to the current catalogue listing for options
Storage: keep in the closed original container under the conditions stated on the manufacturer's label
Handling and Storage
Store the material in its original tightly closed container, kept dry and protected from light, and follow the storage temperature stated on the manufacturer's label and product documentation. Amber glass vials or the supplied container are suitable; transfer portions using clean, dry spatulas to avoid moisture uptake and cross-contamination. Weigh and handle the solid in a well-ventilated area or fume hood, wearing a laboratory coat, safety glasses, and appropriate gloves. Allow refrigerated containers to reach room temperature before opening to prevent condensation on the solid. Prepare solutions immediately before use where possible, label all containers clearly, and consult the manufacturer's safety data sheet before first use and for disposal guidance.
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