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Description
2'-Deoxy-4-thiouridine is a chemical compound widely used in chemical biology and nucleic acid chemistry. It serves as an analog of ribonucleosides, with a structure similar to uridine but featuring a sulfur atom at the fourth position. This unique molecular configuration allows it to function as a valuable tool in laboratory research, particularly in studies related to DNA and RNA replication mechanisms. Its chemical similarity to natural nucleotides makes it a preferred choice for various biochemical experiments.
The compound exhibits chemical stability under controlled conditions, though it is sensitive to UV light and oxidation. These properties make it suitable for use in controlled environments where precise experimental conditions are essential. Its ability to interact with enzymes and proteins involved in transcription and translation further enhances its utility in molecular biology research. This interaction capability allows it to be used as a molecular probe or control in complex biochemical assays.
In Indonesian laboratories, 2'-Deoxy-4-thiouridine is commonly employed in molecular biology, genetics, and pharmacological research. Its role in analytical techniques for nucleic acid detection and characterization is particularly significant. Researchers use it to develop and refine methods for studying genetic material, making it an essential component in scientific investigations across various disciplines.
Laboratory Applications
Molecular Biology Research: This compound is used to study DNA and RNA replication processes due to its structural similarity to natural nucleotides.
Genetic Analysis: It serves as a control or reagent in genetic experiments, aiding in the identification and manipulation of nucleic acids.
Biochemical Assays: Its ability to interact with enzymes and proteins makes it suitable for biochemical studies involving transcription and translation.
Nucleic Acid Detection: It is employed in analytical techniques for detecting and characterizing nucleic acids in complex samples.
Pharmacological Studies: It is used to investigate the effects of nucleotide analogs on cellular processes and drug interactions.
Specifications
Brand: TCI
CAS number: 5580-20-1
Category: Chemistry > Chemical Biology > Nucleic Acid Chemistry
Pack sizes: Not specified
Physical form: Not specified
Storage note: Store in a cool, dark place away from UV light and oxidizing agents.
Handling and Storage
This compound should be stored in a cool, dark environment to prevent degradation due to UV exposure and oxidation. It is recommended to use airtight containers to minimize exposure to air and moisture. Proper labeling of containers is essential to ensure safe handling and prevent contamination. Laboratory personnel should wear appropriate personal protective equipment when handling the compound. Avoid prolonged exposure to light and ensure storage conditions are consistent to maintain its chemical stability. Regular monitoring of storage conditions is advised to ensure the integrity of the material during experimental use.
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