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Description
2'-Deoxy-2'-fluoro-4-thiouridine is a chemical compound widely used in chemical biology and nucleic acid chemistry. It functions as a nucleotide analog with a structure similar to uridine, but with modifications at the oxygen and sulfur atoms. This compound plays a crucial role in laboratory research by enabling the study of nucleic acid interactions and modifications. Its unique chemical properties make it a valuable tool for scientists working on DNA and RNA-related projects.
The compound's ability to bind with enzymes such as RNA polymerase and DNA polymerase makes it a preferred choice for various experimental applications. This interaction allows it to act as a substrate analog or an inhibitor, which is essential for studying enzymatic mechanisms and developing nucleic acid-targeting drugs. Its chemical stability under certain conditions further enhances its usability in a wide range of experimental settings.
In Indonesian laboratories, 2'-Deoxy-2'-fluoro-4-thiouridine is commonly used by researchers in biochemistry, pharmacology, and genetics. It is particularly relevant in studies involving nucleic acid modification, such as the development of antiviral drugs and the testing of nucleotide modifications. Its versatility and reliability make it an essential component in many research protocols.
Laboratory Applications
Nucleic Acid Modification Studies: This compound is ideal for investigating structural and functional changes in DNA and RNA, enabling researchers to explore the impact of nucleotide analogs on genetic material.
Enzymatic Activity Research: Its interaction with polymerase enzymes makes it suitable for studying enzyme mechanisms and substrate specificity in biochemical assays.
Antiviral Drug Development: The compound's ability to mimic nucleotides makes it a key tool in the design and testing of antiviral agents targeting nucleic acid synthesis.
Genetic Engineering Experiments: It is used in experiments that require precise nucleotide substitutions, aiding in the study of gene function and regulation.
Molecular Biology Research: Its role as a nucleotide analog supports various molecular biology techniques, including probe development and hybridization studies.
Specifications
Brand: TCI
CAS number: 10212-16-5
Category: Chemistry > Chemical Biology > Nucleic Acid Chemistry
Pack sizes: Available in various quantities as per supplier specifications
Physical form: Solid powder (as per standard product description)
Storage note: Store in a cool, dry place away from light and moisture
Handling and Storage
This compound should be stored in a cool, dry environment, away from direct light and moisture to maintain its stability and integrity. It is recommended to use airtight containers to prevent exposure to air and humidity. Proper labeling of storage containers is essential to ensure safe handling and prevent cross-contamination. In a laboratory setting, it is important to follow standard safety protocols, including the use of personal protective equipment when handling. The compound should be kept in a secure location that is accessible only to authorized personnel. Regular monitoring of storage conditions is advised to ensure optimal preservation of the material.
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