• 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-(pentyloxycarbonyl)cytidine (CAS 162204-20-8) - TCI D5787 - AMI Scientific
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TCI

CAS 162204-20-8

2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-(pentyloxycarbonyl)cytidine TCI D5787

2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-(pentyloxycarbonyl)cytidine TCI D5787
Rp 1.417.500,00
Rp 1.417.500,00
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2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-N-(pentyloxycarbonyl)cytidine (TCI D5787) is a modified nucleoside compound supplied as a building block for pharmaceutical ingredient research. Its structure is based on cytidine that has undergone several directed modifications: the hydroxyl groups at the 2' and 3' positions are protected as acetates, the 5' position is deoxygenated, the base ring carries a fluorine atom at position 5, and the exocyclic nitrogen is protected as a pentyloxycarbonyl carbamate. In the laboratory, this compound serves as an intermediate or reference compound in synthesis and analysis studies of modified nucleosides for research and experimental purposes.

The property that makes this compound a preferred choice is its neatly arranged functional group protection pattern. The acetates on the sugar allow selective deprotection under mild hydrolysis conditions, while the carbamate on the base nitrogen provides stability during earlier synthetic stages. The presence of the fluorine atom on the pyrimidine ring influences the electronic properties and metabolic stability of the base moiety, a strategy commonly applied in nucleoside design. Because the compound is supplied as a solid with a defined chemical identity, it can be weighed and introduced into reaction sequences in a controlled manner.

In Indonesian laboratories, this material is typically used in academic and institutional research settings working on organic synthesis and pharmaceutical ingredient development. It fits work carried out in university chemistry laboratories, pharmacy faculties, and research institutions studying modified nucleoside chemistry. The compound is intended strictly for research and experimental use, and is generally handled by personnel already familiar with the requirements of synthetic and analytical work involving protected nucleoside intermediates.

  • Modified nucleoside synthesis studies — the pre-installed acetate and carbamate protecting groups allow researchers to build sequences without performing separate protection steps first.
  • Synthetic intermediate in pharmaceutical building block research — supplied with a defined chemical identity as a solid, so it can be weighed accurately and introduced into multi-step reaction routes.
  • Reference compound in analytical work — serves as a comparison material when identifying or characterising modified nucleoside structures during analytical method development for research purposes.
  • Selective deprotection method studies — the sugar acetates can be removed under mild hydrolysis conditions, making the compound suitable for investigating controlled deprotection sequences in the laboratory.
  • Fluorinated pyrimidine chemistry research — the fluorine atom at position 5 of the base ring supports studies on electronic properties and metabolic stability in nucleoside design strategies.

Brand TCI
CAS number 162204-20-8
Molecular formula —
Purity —
Category Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Building Blocks for Pharmaceutical Ingredients (for Research and Experimental Use)
Pack sizes available in the catalogue pack sizes supplied by TCI for this product code (D5787)
Physical form solid
Storage keep in the closed original container under the storage conditions stated on the manufacturer's label

Store the compound in its original, tightly closed container in a cool, dry place away from direct sunlight, moisture, and incompatible substances, following the storage conditions stated on the manufacturer's label. Tightly sealed glass or the supplied original packaging is appropriate; avoid leaving the container open, as the acetate and carbamate protecting groups are sensitive to hydrolytic conditions. Handle the material in a well-ventilated area or fume hood, wearing a laboratory coat, safety glasses, and suitable chemical-resistant gloves. Weigh and transfer using clean, dry equipment to prevent contamination. Consult the manufacturer's safety data sheet before use, and manage residues and empty containers according to the laboratory's chemical waste procedures. This product is intended for research and experimental use only.

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