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Description
4-Fluorosalicylic Acid, supplied under TCI catalogue code F0637, is a fluorinated aromatic building block widely used as a starting material in laboratory-scale organic synthesis. Structurally, the compound is built on a salicylic acid framework: a benzene ring carrying a carboxylic acid group and a phenolic hydroxyl group in adjacent positions, with an additional fluorine atom substituted on the aromatic ring. The combination of two reactive functional groups positioned next to one another makes this material a highly practical starting point for medicinal chemists, materials chemists, and synthetic organic chemists who need an aromatic core that is ready for further modification.
The characteristic that drives the selection of this material lies in the role of the fluorine atom. Fluorine has a small atomic radius but very high electronegativity, so its presence alters the distribution of electron density across the ring without adding meaningful steric bulk. This effect influences the acidity of both the carboxylic acid and the phenol group, modifies the solubility and lipophilicity of derivative molecules, and strengthens resistance to metabolic oxidation in target compounds. The strong carbon–fluorine bond also makes this substituent a durable feature of any structure built from it.
In Indonesian laboratories, this building block is typically used at research and development scale rather than in bulk production. It suits university research groups, medicinal chemistry laboratories, and materials development work where small quantities of a well-defined, ready-to-modify aromatic intermediate are required. Because the two adjacent functional groups can be addressed selectively, the material fits exploratory synthesis programmes in which a single scaffold is elaborated along several different routes.
Laboratory Applications
Medicinal chemistry scaffold preparation — the adjacent carboxyl and phenol groups allow selective derivatisation, while the fluorine substituent improves metabolic stability of the resulting candidate compounds.
Salicylate derivative synthesis — the intact salicylic acid framework lets researchers prepare esters, amides, and salts using established chemistry on a fluorinated variant of a familiar core.
Fluorinated intermediate development — chemists use it to introduce a permanent carbon–fluorine bond early in a route, avoiding harsher late-stage fluorination steps entirely.
Structure–activity relationship studies — substituting a fluorine-bearing analogue for an unsubstituted salicylate lets teams probe how electronic changes affect activity without altering molecular size.
Materials chemistry ligand and monomer work — the bifunctional aromatic core serves as a chelating or linking unit where tuned electron density and oxidative stability are required.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 345-29-9
Catalogue Code: F0637
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack Sizes: Available in standard TCI research-scale packaging; please confirm the pack size when ordering
Storage: Store in a closed container under the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from direct sunlight, moisture, and incompatible materials such as strong bases and strong oxidising agents. Keep the product in its original supplier packaging wherever possible; if transfer is necessary, use clean, dry, chemically compatible containers that are clearly labelled with the compound name and CAS number. Handle the material in a fume hood using appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Avoid generating dust during weighing and transfer operations, and wash hands thoroughly after handling. Always consult the manufacturer's safety data sheet before use and follow institutional procedures for chemical waste disposal.
