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Description
TCI F0780 2-Fluoro-5-(trifluoromethyl)phenol is a doubly fluorinated phenol that carries a fluorine atom at the position ortho to the hydroxyl group, together with a trifluoromethyl group positioned further around the benzene ring. The compound is used in the laboratory as a building block for assembling aryl ethers, aryl esters, and a range of substituted aromatic frameworks. The phenolic hydroxyl group serves as the principal reaction site, while the two fluorinated substituents govern the electronic character of the ring and pass fluorinated character on to the final molecules constructed from it.
The most notable property of this compound is the enhanced acidity of its phenol, a direct consequence of the presence of two strongly electron-withdrawing groups. A more acidic phenol is more readily deprotonated to the corresponding phenoxide by mild bases, so Williamson etherification and nucleophilic aromatic substitution reactions proceed under gentler conditions. The trifluoromethyl group is known to increase lipophilicity and stability toward oxidative metabolism, two properties highly valued in the design of active ingredients. The ortho fluorine atom, meanwhile, exerts a local electronic influence while also providing an analytical marker.
In Indonesian laboratories, this building block is typically encountered in university and institutional research groups working on synthetic organic chemistry, medicinal chemistry, and materials preparation, as well as in industrial R&D units developing fluorinated intermediates. It is normally purchased in small research quantities for exploratory route development and analytical reference work rather than production use, and is handled within a standard fume-hood workflow alongside the usual anhydrous solvents and base reagents.
Laboratory Applications
- Williamson ether synthesis — the enhanced phenol acidity allows clean phenoxide formation with mild bases, giving fluorinated aryl alkyl ethers under conditions gentler than ordinary phenols require.
- Aryl ester preparation — the phenolic hydroxyl reacts readily with acylating agents, letting researchers install the doubly fluorinated aromatic ring onto ester-linked scaffolds in a single, direct step.
- Nucleophilic aromatic substitution chemistry — the electron-poor ring created by two withdrawing substituents makes the derived phenoxide a useful partner for building substituted aromatic frameworks efficiently.
- Medicinal chemistry intermediate synthesis — the trifluoromethyl group raises lipophilicity and resistance to oxidative metabolism, properties routinely sought when constructing candidate structures for biological evaluation.
- Fluorinated scaffold construction and analytical referencing — the ortho fluorine atom passes fluorinated character to downstream molecules while also serving as a convenient analytical marker during reaction monitoring.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 141483-15-0
- Catalogue code: F0780
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research-scale packaging; please confirm the exact sizes currently listed for this catalogue code
- Storage note: keep the container tightly closed in a cool, dry, well-ventilated place away from light and incompatible materials
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well-ventilated area, protected from direct light and kept away from strong oxidising agents and strong bases. Amber glass or the supplier's original packaging is appropriate; where the compound is transferred for use, a chemically resistant, well-sealed vessel should be used and clearly labelled. All handling, weighing, and transfer operations should be carried out in a functioning fume hood, wearing safety goggles, chemically resistant gloves, and a laboratory coat. Avoid contact with skin and eyes and avoid breathing vapour. Close the container promptly after use to limit moisture uptake, and consult the manufacturer's safety data sheet before first use for complete handling, exposure, and disposal guidance.
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