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Description
TCI F0813 2-Fluoro-4-methylbenzoic Acid is a fluorinated aromatic building block built around three complementary structural elements: a carboxylic acid group, a fluorine atom in the ortho position, and a methyl group positioned para to the fluorine. This particular arrangement of substituents gives the molecule a distinctive and predictable reactivity pattern, which makes it a practical starting material for the synthesis of nitrogen-containing compounds, amides, esters, and heterocyclic frameworks. In routine laboratory work, it serves as an efficient entry point toward more elaborate target molecules without requiring long preliminary functionalization sequences.
The characteristic that makes this compound an attractive choice is the influence of the ortho fluorine atom on the neighbouring carboxyl group. Its position increases the acidity of the carboxylic acid through an inductive effect while simultaneously exerting both steric and electronic influence during acid activation steps, which is useful when researchers wish to control selectivity in amidation reactions. The methyl group on the ring provides opportunities for further transformation, for example oxidation to a second carboxyl function or benzylic halogenation, so that a single starting material can serve several synthetic directions.
In Indonesian laboratories, a building block of this type is typically used in university research groups, pharmaceutical and agrochemical development work, and method-development activities where fluorinated intermediates are required. It is commonly handled at small to moderate scale on the bench, either for exploratory route scouting or for the preparation of reference compounds. Because it arrives ready to use as a defined building block, it shortens the preparation stage of a project and lets researchers concentrate on the coupling and cyclization steps that matter most.
Laboratory Applications
Amide coupling and amidation chemistry: the activated carboxyl group reacts readily with amines, while the neighbouring fluorine atom helps researchers control selectivity during the acid activation step.
Esterification and protecting-group work: the carboxylic acid is straightforwardly converted into esters, providing a convenient handle for downstream chemistry or for adjusting solubility during purification.
Synthesis of heterocyclic frameworks: the compound acts as a defined aromatic core that can be carried into ring-forming sequences leading to nitrogen-containing heterocyclic targets.
Preparation of nitrogen-containing compounds: the fluorinated aromatic ring is incorporated as an intact fragment, saving several preliminary functionalization steps in a longer synthetic route.
Further ring functionalization studies: the methyl substituent offers a site for benzylic halogenation or oxidation to a second carboxyl group, allowing one material to serve multiple directions.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 7697-23-6
Chemical name: 2-Fluoro-4-methylbenzoic Acid
Catalogue code: F0813
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard TCI research-scale packaging; please confirm the size required when ordering
Storage: keep in a tightly closed container in a cool, dry, well-ventilated area
Handling and Storage
Store the material in its original tightly closed container in a cool, dry and well-ventilated place, away from direct sunlight, moisture and incompatible substances such as strong bases and strong oxidizing agents. Amber glass or the supplier's original container is suitable for keeping the material protected during storage. Handle in a fume hood and wear appropriate personal protective equipment, including safety glasses, gloves and a laboratory coat. As a carboxylic acid, the compound may cause irritation on contact with skin, eyes or the respiratory tract, so avoid generating dust and wash thoroughly after handling. Close the container promptly after weighing to limit moisture uptake, and always consult the manufacturer's safety data sheet before use.
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