Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.
Couldn't load pickup availability
Description
TCI F0817 2-Fluoro-6-methylaniline is a fluorinated aniline building block carrying a primary amine group flanked by a fluorine atom on one side and a methyl group on the other. This arrangement of two substituents at both ortho positions creates a distinctive steric and electronic environment around the amine group, a feature deliberately sought after in many synthesis programmes. Anilines are among the most productive functional groups in organic chemistry because they can be converted into amides, sulfonamides, ureas, diazonium salts, and a wide range of nitrogen-containing heterocyclic rings, making this compound an efficient starting point toward diverse target molecules.
The property that makes this material attractive is the balance it strikes between reactivity and control of selectivity. The fluorine atom at the ortho position withdraws electron density, thereby lowering the basicity and nucleophilicity of the amine group in a measurable way, while the methyl group provides steric hindrance that can steer reactions away from particular positions on the ring. The combination of the two also restricts free rotation in the amides derived from it, a property that is exploited in the design of compounds with controlled conformation, including active ingredients for crop protection and related fine chemical targets.
In Indonesian laboratories, this building block is typically used in academic and industrial research settings where multi-step organic synthesis is carried out on a small to moderate scale. It suits university research groups preparing heterocyclic scaffolds, pharmaceutical and agrochemical R&D units screening substituted aniline intermediates, and contract research facilities that need a reliable, well-characterised fluorinated starting material supplied in standard laboratory pack sizes rather than bulk industrial quantities.
Laboratory Applications
Amide and sulfonamide synthesis — the primary aromatic amine couples readily with acyl chlorides, anhydrides, and sulfonyl chlorides, while the ortho substituents give the resulting amide a restricted, well-defined conformation.
Nitrogen heterocycle construction — the aniline nitrogen and the adjacent ring positions serve as anchor points for building benzimidazoles, quinolines, indoles, and related nitrogen-containing ring systems in cyclisation routes.
Urea and carbamate preparation — reaction with isocyanates or chloroformates converts the amine into ureas and carbamates, with the fluorine-modulated nucleophilicity giving more predictable control over the addition step.
Diazonium salt chemistry — diazotisation of the amine opens access to Sandmeyer-type substitutions and azo coupling, allowing the fluorinated, methyl-substituted ring to be carried into further transformations.
Agrochemical and pharmaceutical intermediate research — the combined electronic and steric profile makes this aniline a useful scaffold in exploratory work on conformationally controlled active ingredients and structure–activity studies.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 443-89-0
Chemical name: 2-Fluoro-6-methylaniline
Product code: F0817
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes: available in standard TCI laboratory research pack sizes; please confirm the currently listed size when ordering
Storage: keep in a cool, dark place in a tightly sealed container
Handling and Storage
Store the container tightly closed in a cool, dark, and well-ventilated place, away from heat sources, direct sunlight, and incompatible materials such as strong oxidising agents and strong acids. Keep the material in its original manufacturer packaging or in a compatible, clearly labelled chemical container, and reseal promptly after each use to limit exposure to air and moisture. Handle in a fume hood using appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, and a laboratory coat, and avoid inhalation of vapour and contact with skin or eyes. Consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials according to applicable laboratory chemical waste procedures.
