• 6-Fluoro-4-chromanone (CAS 66892-34-0) - TCI F0831 - AMI Scientific
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TCI

CAS 66892-34-0

6-Fluoro-4-chromanone TCI F0831

6-Fluoro-4-chromanone TCI F0831
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Rp 584.850,00
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6-Fluoro-4-chromanone is a heterocyclic building block built around the chroman-4-one skeleton, a benzene ring fused to a six-membered pyran ring and carrying a ketone group. This framework is a close relative of the chromones and flavonoids that appear widely among natural products and pharmaceutical compounds. This fluorinated variant from TCI is used in the laboratory as a starting point for assembling chroman-core molecules that already carry a fluorine atom from the outset, so that researchers can focus directly on modifying the ketone group and the ring system without an additional and troublesome fluorination step.

The property that makes this material attractive is its cyclic ketone group, which is reactive yet controllable. The carbonyl at the four position can be reduced to an alcohol, converted into an oxime or a hydrazone, processed through aldol condensation, or used as an entry point for the construction of new rings such as pyrazoles and isoxazoles. The hydrogen atoms adjacent to the carbonyl are relatively easy to remove, which makes directed alkylation possible. The fluorine atom on the aromatic ring alters the electronic character of the system, increases lipophilicity in a measurable way, and often improves the metabolic stability of the final molecule.

As a solid material, this building block is convenient to weigh out and handle on the bench, which suits the working routine of Indonesian laboratories. It is typically found in academic and pharmaceutical research groups carrying out organic synthesis and medicinal chemistry work, where fluorinated intermediates are needed for the preparation of compound series. Its role is that of an intermediate rather than an end product, supplying the chroman core for subsequent synthetic steps.

  • Medicinal chemistry scaffold synthesis: the pre-installed fluorine and the reactive chroman-4-one core let researchers build fluorinated analogue series without performing a separate fluorination step themselves.
  • Heterocycle construction: the four-position carbonyl serves as an entry point for forming new rings such as pyrazoles and isoxazoles fused to the existing chroman framework.
  • Carbonyl derivatisation studies: the ketone can be converted into oximes or hydrazones, giving a straightforward route to families of derivatives from a single common intermediate.
  • Reduction chemistry: the cyclic ketone can be reduced to the corresponding alcohol, which makes this material useful for teaching and for optimising reduction conditions on a chroman system.
  • Directed alkylation work: hydrogen atoms next to the carbonyl are comparatively easy to remove, allowing controlled alkylation at that position for structure–activity exploration.

Brand TCI
CAS number 66892-34-0
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes catalogue pack sizes available on request
Physical form solid
Storage store in a closed container under the conditions stated on the manufacturer's label

Keep this building block in its original tightly closed container, protected from moisture and stored away from direct sunlight and heat sources. Amber glass or the supplied original packaging is suitable, and the container should be resealed promptly after each weighing so that the solid does not pick up atmospheric moisture. Handle the material in a fume hood using gloves, safety glasses, and a laboratory coat, and avoid generating dust when transferring the solid. Follow the manufacturer's safety data sheet for the specific hazard information and disposal route, and label any secondary containers clearly.

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