Hydrazine Monohydrate from TCI is a hydrazine hydrate supplied as a colourless liquid, and it ranks among the most versatile reagents available in a chemistry laboratory. Within the field of glycoscience, it serves as the reagent for hydrazinolysis, the process that releases glycan chains from glycoproteins so that the sugar structures can be analysed separately from their protein component. Beyond that specific role, hydrazine hydrate is widely used as a reducing agent, as a source of the N–N unit in heterocyclic synthesis, and as a deprotection reagent for phthalimide groups. Because it is supplied in liquid form, the material is easy to measure by pipette for reactions at any scale.
The characteristics that make this reagent a preferred choice begin with its strong nucleophilic reactivity toward carbonyl and imide groups, which drives the condensation and deprotection chemistry it is chosen for. It also reduces without leaving any metal residue behind, since its by-products are simply nitrogen and water — a considerable advantage when the reaction product must stay free of metallic contamination. Its solubility in water and in alcohols is excellent, and the liquid form allows rapid, homogeneous mixing so that reactions can proceed at relatively low temperatures rather than requiring forcing conditions.
In Indonesian laboratories this reagent is typically found in glycoscience and synthetic organic chemistry work, where the same properties that make it useful also define how it must be handled. Hydrazine hydrate evaporates readily and is highly reactive toward oxidising materials, so its use always demands that work be carried out inside a fume hood. Analysts measuring it by pipette for glycan release or heterocyclic synthesis should plan every transfer with that requirement in mind.
- Hydrazinolysis of glycoproteins — the reagent releases intact glycan chains from the protein backbone so that sugar structures can be analysed independently of the protein portion.
- Reduction reactions — hydrazine hydrate reduces without leaving metal residues behind, because its by-products are only nitrogen and water, keeping the product free of metallic contamination.
- Heterocyclic synthesis — it supplies the N–N unit required to build nitrogen-containing ring systems, making it a standard building block in synthetic organic chemistry programmes.
- Phthalimide deprotection — its strong nucleophilic reactivity toward imide groups cleaves phthalimide protecting groups efficiently, liberating the free amine for the next synthetic step.
- Small- and large-scale reaction work — the liquid form is easily measured by pipette and mixes rapidly and homogeneously, allowing reactions to run at relatively low temperatures.
| Brand | TCI |
|---|---|
| CAS number | 7803-57-8 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Chemical Biology > Glycoscience |
| Pack sizes | — |
| Physical form | colourless liquid (hydrazine hydrate) |
| Storage | keep tightly closed and away from oxidising materials; handle in a fume hood |
- Catalogue number: H0172
Store Hydrazine Monohydrate in a tightly closed container, kept well away from oxidising materials, as the reagent is highly reactive toward them. Because the liquid evaporates readily, containers should be resealed immediately after each transfer and kept in a well-ventilated storage area reserved for reactive chemicals. All dispensing, pipetting, and reaction set-up should be performed inside a fume hood without exception. Analysts should wear appropriate laboratory gloves, eye protection, and a lab coat, and should avoid any contact between the reagent and oxidising agents anywhere in the work area.
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