TCI H0204 Hydrazine Monohydrate (79%) is a solution of hydrazine in its monohydrate form, supplied as a liquid with exceptionally strong reducing power and high nucleophilic character. In the laboratory it is recognised as one of the most versatile reagents available, and at the same time one of the most demanding in terms of careful handling. Within glycoscience, hydrazine monohydrate plays a central role in hydrazinolysis, the release of glycan chains from glycoproteins so that the carbohydrate structures can be analysed separately from the protein backbone. This role makes it a key material in glycomics research and in glycoprotein characterisation work that depends on recovering intact glycans.
The property that leads researchers to select this reagent is the combination of reducing strength with the ability to cleave amide bonds selectively under controlled conditions. As a nucleophile carrying two adjacent nitrogen atoms, hydrazine reacts rapidly with aldehydes and ketones to form hydrazones, and it is used widely in Wolff-Kishner reduction chemistry and in the construction of heterocyclic ring systems. In the liquid monohydrate form the compound is easier to pour and to measure accurately than the anhydrous material, although it must still be treated at every stage as a hazardous substance. Hydrazine is highly toxic, corrosive, and readily absorbed, so the practical convenience of the liquid form never removes the need for strict control.
In Indonesian laboratories this reagent is generally found in university research groups, glycobiology and biochemistry units, and analytical laboratories that carry out structural work on carbohydrates and glycoproteins. It is normally handled in a fume hood by trained personnel, dispensed in small working volumes rather than bulk transfers, and reserved for procedures where its reducing power or selective amide cleavage is genuinely required. Institutions that stock it typically pair it with defined handling procedures and restricted access to the storage area.
- Hydrazinolysis of glycoproteins — releases glycan chains from the protein backbone so the intact carbohydrate structures can be recovered and analysed independently for glycomics work.
- Glycoprotein characterisation and glycomics profiling — provides the cleavage chemistry needed to obtain whole glycans for downstream structural study rather than fragmented carbohydrate pieces.
- Hydrazone formation from aldehydes and ketones — the doubly nitrogenated nucleophile reacts rapidly with carbonyl groups, making it a dependable reagent for derivatisation and condensation chemistry.
- Wolff-Kishner reduction procedures — the strong reducing character of hydrazine drives the conversion of carbonyl compounds in this classical synthetic transformation under laboratory conditions.
- Heterocyclic ring construction in synthetic chemistry — the two adjacent nitrogen atoms serve as a building block for forming nitrogen-containing ring systems in preparative organic synthesis.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 7803-57-8 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Chemical Biology > Glycoscience |
| Pack sizes | available in the standard laboratory pack sizes offered by TCI for this catalogue item |
| Physical form | liquid, hydrazine monohydrate solution (79%) |
| Storage | keep tightly closed in the original container, in a cool, well-ventilated place away from incompatible materials |
Hydrazine monohydrate is highly toxic, corrosive, and readily absorbed, and must be treated as a hazardous material throughout handling and storage. Store the container tightly closed in a cool, well-ventilated area, away from oxidising agents, acids, heat sources, and ignition sources, and keep it in the original supplier container or another compatible chemically resistant vessel. All dispensing should be carried out inside a functioning fume hood by trained personnel wearing chemical-resistant gloves, safety goggles, and a laboratory coat. Although the liquid monohydrate is easier to pour and measure than the anhydrous form, that convenience does not reduce the need for strict control. Avoid skin contact and inhalation of vapour, transfer only the volume required for the procedure, and keep spill control materials and eyewash facilities accessible.
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