4-(4-Hydroxyphenyl)cyclohexanone is a building block that combines an aliphatic cyclohexanone ring and an aromatic phenol ring within a single molecule. This pairing makes it a particularly useful intermediate, because it carries two distinct kinds of reactivity at the same time: a cyclic ketone that is readily modified, and a phenolic group that is ready for alkylation or acylation. In synthetic laboratories, compounds of this type are used to construct multi-stage molecular frameworks, ranging from pharmaceutical intermediates through to specialty monomers for polymer materials research.
The property that leads chemists to select this compound is the ketone group on the cyclohexane ring, which opens the door to reductive amination, reduction to the corresponding cyclic alcohol, enolate formation, and olefination. The phenolic group at the opposite end of the molecule provides an additional anchoring point while also influencing solubility and hydrogen-bonding capability. The symmetrical para arrangement yields a solid with good crystallinity, so purification of derivative products generally proceeds smoothly. Packs of 5 g and 25 g offer a choice matched to the stage of the work, from initial reaction scouting through to synthesis on a larger scale.
In Indonesian laboratories, a compound of this kind belongs to the working stock of research groups that build molecules step by step rather than run a single fixed procedure. It suits university organic synthesis groups, pharmaceutical research units developing intermediates, and materials laboratories preparing specialty monomers. The smaller pack supports method development and trial reactions, while the larger pack serves groups that have settled on a route and need to carry it through at a more substantial scale.
Related TCI products
- Pharmaceutical intermediate synthesis — the dual reactivity lets researchers elaborate the ketone and the phenol in separate, controlled steps when building candidate molecules toward a target scaffold.
- Reductive amination routes — the cyclohexanone carbonyl converts cleanly to an amine-bearing centre, giving access to substituted aminocyclohexyl frameworks that retain the intact aromatic phenol group.
- Specialty monomer preparation — the phenolic hydroxyl serves as the polymerisable or linkable handle for polymer materials research, while the rigid cyclohexyl core contributes structural stability.
- Selective functionalisation studies — alkylation or acylation of the phenol group provides a convenient point for attaching side chains without disturbing the ketone elsewhere in the molecule.
- Carbonyl transformation work — enolate formation, olefination, and reduction to the cyclic alcohol all make this a practical substrate for teaching and developing standard carbonyl methodology.
| Brand | TCI |
|---|---|
| CAS number | 105640-07-1 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | 5 g and 25 g |
| Physical form | crystalline solid |
| Storage | keep in a tightly closed container in a cool, dry place away from light |
- Product code: H1316
Store the container tightly closed in a cool, dry, well-ventilated place, away from direct sunlight and sources of heat or ignition. The original supplier container is the most suitable vessel; if transfer is necessary, use a clean amber glass bottle with a chemically resistant closure and label it clearly. Because the phenolic group is sensitive to prolonged exposure to air and light, minimise the time the container stays open and reseal it promptly after weighing. Handle the solid in a fume hood, wearing safety goggles, nitrile gloves, and a laboratory coat, and avoid generating or inhaling dust. Keep the material separated from strong oxidising agents and strong bases. Allow a refrigerated container to warm to room temperature before opening to prevent moisture condensation on the contents.
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