TCI H1334, CAS 704-13-2, is 3-Hydroxy-4-nitrobenzaldehyde, a benzaldehyde carrying a hydroxy group and a nitro group at adjacent positions on its aromatic ring. The combination of three distinct functional groups within a single small molecule makes it a highly useful non-heterocyclic building block for synthetic chemists. In the laboratory it serves as a starting point for the construction of more complex molecules, because each functional group can be modified separately at a different stage, allowing synthetic routes to be designed with a high degree of flexibility.
The property that drives its selection lies in the orthogonal reactivity between its functional groups. The aldehyde group acts as a classical reaction centre for condensation, olefination, reduction, and reductive amination; the phenolic hydroxy group provides a site for selective etherification or acylation; while the nitro group behaves as a strong electron-withdrawing substituent that alters the acidity of the phenol and at the same time serves as a precursor to an amino group through reduction. The ortho relationship between the nitro and hydroxy groups also opens a pathway to the formation of fused heterocyclic systems such as benzoxazoles following reduction.
In Indonesian laboratories, this compound is typically used in synthetic organic chemistry research at universities, government research institutes, and industrial R&D units developing new molecules. It is a crystalline solid that is stable at room temperature, which makes it practical to store and handle under routine local laboratory conditions. Researchers generally draw on it in multistep synthesis work, where a single intermediate must offer several independently addressable reaction sites.
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- Multistep synthesis intermediate preparation: the three independent functional groups allow chemists to build complex target molecules by addressing one reactive site at a time across separate stages.
- Condensation and olefination chemistry: the aldehyde group serves as a classical carbonyl reaction centre, making this compound a convenient partner in reactions that extend the carbon framework.
- Reductive amination studies: the aldehyde function can be converted into substituted amines, giving researchers direct access to nitrogen-containing analogues built on a substituted aromatic core.
- Selective phenol derivatisation: the phenolic hydroxy group offers a defined point for etherification or acylation, letting researchers modify polarity and solubility without disturbing other groups.
- Fused heterocycle construction: the ortho arrangement of nitro and hydroxy groups permits formation of benzoxazole-type ring systems after reduction of the nitro function.
| Brand | TCI |
|---|---|
| CAS number | 704-13-2 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | please refer to the packaging options listed on this product page |
| Physical form | crystalline solid |
| Storage | stable at room temperature; refer to the manufacturer's label and safety data sheet for the recommended conditions |
- Product code: H1334
Store this compound in its original tightly closed container, kept in a cool, dry, and well-ventilated area away from direct sunlight, moisture, and incompatible materials. Amber glass or the manufacturer's supplied container is suitable for maintaining product integrity, and the container should be resealed promptly after each use to limit exposure to air and humidity. Handle the material inside a fume hood while wearing safety goggles, a laboratory coat, and chemically resistant gloves. Avoid inhalation of dust and any contact with skin or eyes, use clean and dry spatulas when weighing to prevent cross-contamination, and always consult the manufacturer's safety data sheet before use, transfer, or disposal.
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