TCI M1029 4-Methyl-5-vinylthiazole, CAS number 1759-28-0, is a heterocyclic compound built around a thiazole ring — a five-membered ring containing both a sulfur atom and a nitrogen atom — carrying a methyl group at the four position and a vinyl group at the five position. The combination of an aromatic heterocyclic ring with a terminal double bond makes it a dual-function building block in the laboratory: the thiazole portion contributes electronic character and coordination capability, while the vinyl group provides a site for addition, polymerization, and cross-coupling reactions. The compound is also closely associated with the thiazole framework found in thiamine, so it appears frequently in synthetic studies of vitamin-related compounds and aroma materials.
The property that makes this material a preferred choice is the reactivity of its vinyl group, which is relatively easy to direct — through hydrogenation, hydroformylation, Heck-type reactions, metathesis, or nucleophilic addition — without first having to dismantle the thiazole ring itself. That selectivity lets chemists elaborate one end of the molecule while the heterocyclic core remains intact as a structural anchor. The nitrogen atom in the ring is weakly basic and capable of coordinating with transition metals, a property that is useful in ligand design and in catalysis. It is a liquid at room temperature, so it is straightforward to pipette and dispense.
In Indonesian laboratories, this building block is typically encountered in university and institutional research settings where heterocyclic synthesis, ligand preparation, and flavour or vitamin-related chemistry are studied. Its liquid form suits small-scale reaction work on a standard bench or Schlenk line, where measured volumes are transferred directly into reaction vessels. Research groups working on thiazole chemistry generally keep it as a stock intermediate rather than preparing the ring system from scratch for each project.
- Heterocyclic synthesis — the intact thiazole core serves as a ready-made ring system, so researchers can build larger targets without constructing the sulfur-nitrogen heterocycle themselves at each step.
- Cross-coupling chemistry — the terminal vinyl group participates in Heck-type reactions and related couplings, allowing new carbon-carbon bonds to be formed at a well-defined and predictable position.
- Ligand design and coordination studies — the weakly basic ring nitrogen coordinates to transition metals, making this compound a practical starting point for preparing thiazole-based ligands for catalysis.
- Polymerization and addition reactions — the terminal double bond offers a reactive handle for polymerization and nucleophilic addition, introducing the heterocyclic unit into larger chains or adducts.
- Vitamin and aroma-related synthetic studies — its structural relationship to the thiazole framework of thiamine makes it a frequent reference substrate in work on vitamin-related compounds and flavour materials.
| Brand | TCI |
|---|---|
| CAS number | 1759-28-0 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Heterocyclic Building Blocks |
| Pack sizes | available in standard TCI research-scale packaging; please confirm the size required when ordering |
| Physical form | liquid at room temperature |
| Storage | keep in a tightly closed original container, away from heat and light |
- Chemical name: 4-Methyl-5-vinylthiazole (product code M1029)
Store the container tightly closed in a cool, dry, well-ventilated area, protected from heat, direct sunlight, and ignition sources. Because the material is a liquid, keep it in its original chemically compatible bottle with the cap firmly sealed to limit evaporation and vapour escape; transfer only the volume needed for immediate use. Handle inside a fume hood and wear safety glasses, gloves, and a laboratory coat. The terminal vinyl group can react under heat or with reactive reagents, so keep the compound away from strong oxidizing agents and avoid prolonged exposure to elevated temperature. Follow the supplier safety data sheet and institutional chemical waste procedures for disposal of residues and used containers.
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