Megestrol Acetate is a synthetic progestin steroid belonging to the pregnane class, carrying an acetate group at the seventeen position. Within this catalogue the compound is classified as a pharmaceutical research reagent intended for experimental use only, and not as a therapeutic preparation. In the laboratory setting, this material serves as a reference compound and test ligand in research addressing progesterone receptors, steroid metabolism, and the development of analytical methods. The availability of well-characterised reference materials is an absolute requirement if assay results are to be scientifically defensible and reproducible by other laboratories.
The properties that make this compound valuable to researchers centre on its rigid steroid framework combined with a highly distinctive pattern of functional groups, including a conjugated dienone system on the A ring, an additional methyl group, and an acetate ester on the side chain. That conjugated structure gives the molecule strong ultraviolet absorption, so the compound is readily detected in liquid chromatography using ultraviolet or photodiode array detectors. The acetate ester group improves solubility in organic solvents and influences the release profile observed in formulation studies. The rigidity of the framework contributes to consistent, well-defined behaviour under analytical conditions.
In Indonesian laboratories, this reagent is typically employed in university research groups, pharmaceutical analysis units, and institutional research centres working on steroid chemistry and method development. It is commonly used as a comparison standard when analysts establish or verify chromatographic procedures, and as a probe compound in receptor-focused investigations. Because the material is supplied strictly for experimental purposes, it is handled under the ordinary controls applied to research-grade reagents rather than those governing clinical preparations.
- Progesterone receptor research — the compound acts as a synthetic progestin test ligand, allowing investigators to probe receptor binding behaviour with a defined and well-characterised reference structure.
- Steroid metabolism studies — its pregnane skeleton and acetate ester make it a suitable substrate and comparison compound for investigations tracing metabolic transformations of steroid molecules.
- Analytical method development — the strongly conjugated dienone system provides robust ultraviolet absorption, making the compound an excellent reference standard when establishing liquid chromatographic separation procedures.
- Chromatographic detection work — ultraviolet and photodiode array detectors respond well to this material, so it is convenient for verifying detector performance and confirming peak identity during routine method checks.
- Formulation research — the acetate ester group improves solubility in organic solvents and affects release behaviour, making the compound useful for experimental studies of steroid release profiles.
| Brand | TCI |
|---|---|
| CAS number | 595-33-5 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use) |
| Pack sizes | available in standard TCI research pack sizes; please refer to the catalogue listing for the options offered |
| Physical form | — |
| Storage | store according to the manufacturer's instructions stated on the product label and accompanying documentation |
- Catalogue code: M1949
Store the container in a cool, dry place away from direct sunlight and sources of heat, following the storage conditions stated by the manufacturer on the product label. Keep the material in its original tightly closed container, or in a clean amber glass vessel where light protection is needed, and close it promptly after each use to limit moisture uptake. Handle the compound in a fume hood or a well-ventilated area, wearing a laboratory coat, gloves, and safety eyewear. As a steroid research reagent, it should be weighed carefully to avoid generating airborne dust, kept separate from foodstuffs and incompatible chemicals, and used only by trained personnel who have reviewed the accompanying safety documentation. Dispose of residues and contaminated consumables through the laboratory's designated chemical waste route.
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Product Categories
- Biochemicals and ReagentsPharmaceutical Research Reagents (for Experimental Use)Antitumor Research Reagents (for Experimental Use)
- Biochemicals and Reagents
- Biochemicals and ReagentsSteroidsPregnanes (Progestogen) [Steroids]
- Cell BiologyCancer ResearchAntitumor Agents for Research
- Cell BiologyCell Signaling and NeuroscienceCytokines, Growth Factors and Hormones
- Pharmaceutical Development and Drug Discovery ResearchPharmaceutical Research Reagents (for Experimental Use)Antitumor Research Reagents (for Experimental Use)
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