Capsule Reagent Containing HOTU as a Condensing Agent for Condensation Reactions
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Reagents for Condensation Reactions (HPMC encapsulated) (HOTU) [R0297] is a condensing agent supplied in a water-soluble HPMC capsule, with each capsule containing ca. 0.25 mmol of HOTU. The capsule format means the condensing agent does not need to be weighed out. In the TCI example, 4-bromobenzoic acid and morpholine were condensed in DMF at 30 °C for 2 hours, using N,N-diisopropylethylamine (= DIPEA) [D1599] as base, to afford (4-bromophenyl)(morpholino)methanone in 80% yield after silica gel chromatography. The capsule was added directly to the reaction mixture, and the HPMC shell was removed by filtration through Celite after the reaction. The reaction was monitored by UPLC. Because the capsule material, hydroxypropyl methylcellulose (HPMC), is water-soluble, TCI noted that a more diluted sodium sulfate solution during workup may reduce clogging of the separating funnel caused by precipitated sodium sulfate.
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Source
- TCI Practical Example: www.tcichemicals.com/ID/en/product/tci-topics/TCIPracticalExample_20250224
- TCI product page B0553: tcichemicals.com/ID/en/p/B0553
For research and laboratory use only, not for human consumption.
