Sulfur-Poisoned Platinum Catalyst on Activated Carbon for Hydrogenation Suppressing Dehalogenation
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Platinum 3% on Carbon (Modified by Sulfur) (Pt/C, TCI code: P3305) is a heterogeneous catalyst with 3 wt% platinum supported on activated carbon and poisoned with sulfur. Hydrogenation can be used for various transformations, including reduction of multiple bonds and nitro groups, debenzylation, deprotection of Cbz groups, and dehalogenation.¹) ²) Heterogeneous noble metal catalysts on activated carbon are commonly used because they can be removed by filtration after the reaction, making post-treatment and purification easy. However, hydrogenation is often run under high pressure in a hydrogen atmosphere, so the desired reduction and undesired dehalogenation can proceed simultaneously. Because of the sulfur poisoning, almost no dehalogenation occurs even when the substrate carries halogen groups, making this catalyst suitable for chemoselective hydrogenation in both laboratory and process scale. It is supplied in wetted form because it can be flammable when dried.
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References
- Heterogeneous catalytic hydrogenations
- G. J. Hutchings, R. P.
- K. Wells, J. E. Bailie, Sci. Prog. 1999, 82, 233.
- Development of the Applications of Pd/C in Organic Synthesis
- X. Liu, D. Astruc, Adv. Synth. Catal. 2018, 360, 3426.
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Source
- TCI Product Highlights: www.tcichemicals.com/ID/en/product/tci-topics/ProductHighlights_20250428
- TCI product page P3305: tcichemicals.com/ID/en/p/P3305
For research and laboratory use only, not for human consumption.
