Ossila 1-[2-(Trifluoromethyl)phenyl]imidazole B1661

1-[2-(Trifluoromethyl)phenyl]imidazole (CAS 25371-96-4), also known as TRIM, is a fluorinated heterocyclic building block supplied as a white powder with >98% purity. Its structure joins an imidazole ring to the ortho position of a trifluoromethyl-substituted benzene ring through a single carbon-carbon bond, giving a rigid scaffold with multiple functional groups for straightforward synthesis.

This arrangement binds strongly to transition metals such as iridium (Ir) and ruthenium (Ru). Homoleptic iridium(III)-phenylimidazole complexes reach photoluminescence quantum yields of 53% and, in OLED devices, a current efficiency of 20 cd/A at 1000 cd/m2. A cyclometalated ruthenium complex built on phenylimidazole acts as a chromogenic fluoride sensor in acetonitrile, shifting from 565 nm to 618 nm as the solution turns from red to green.

In biomedical research, the compound is widely studied as an inhibitor of neuronal nitric oxide synthase, an enzyme linked to depression and anxiety, and has shown a significant antidepressant-like effect at 30 mg/kg/day.

• Ligand synthesis for cyclometalated iridium(III) emitters used in OLEDs.
• Preparation of cyclometalated ruthenium complexes for chromogenic fluoride sensing.
• Ligand and building block work for dye-sensitized solar cells (DSSCs).
• Drug discovery and biochemistry studies as a neuronal nitric oxide synthase inhibitor.

• Product code: B1661
• Full Name: 1-[2-(Trifluoromethyl)phenyl]-1H-imidazole
• M​olecular Weight: 212.17 g/mol
• Synonyms: TRIM, 1-(1H-Imidazol-1-yl)-2-(trifluoromethyl)benzene
• Classification / Family: Fluorinated building block, Heterocyclic building block, OLEDs, APIs
• Melting Point: 50 °C – 53 °C

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