Ossila 1-Bis(4-fluorophenyl)methyl piperazine B2441

1-Bis(4-fluorophenyl)methyl piperazine (CAS 27469-60-9), also known as difluorobenzhydrylpiperazine, is a fluorinated benzhydrylpiperazine building block supplied as a white powder with >98% purity. Its structure joins a piperazine ring to a diphenylmethane unit carrying fluorine atoms at both para positions, giving several functional groups that make synthesis straightforward.

The compound is a key intermediate in preparing diphenylpiperazine drugs such as flunarizine and lomerizine, which are calcium antagonists (calcium channel blockers) used clinically to treat migraines. These drugs are made in a single step, coupling the piperazine with halogenated analogues of the second fragment through nucleophilic substitution.

It has also been used to build piperazinylacetamides studied as anticancer agents, with a reported half maximal growth inhibitory concentration (GI50) of 4.36 µM. Published work further describes its use in benzhydryl piperazine cannabinoid CB1 receptor inverse agonists, nitrobenzenesulfonamide hybrids and antimicrobial N-alkyl and N-sulfonyl derivatives.

• Synthesis intermediate for APIs in medicinal chemistry and drug discovery.
• Preparation of calcium channel blockers such as flunarizine and lomerizine via nucleophilic substitution.
• Synthesis of piperazinylacetamides evaluated as anticancer compounds.
• Development of N-alkyl and N-sulfonyl derivatives studied for antimicrobial activity.
• Building block for benzhydryl piperazine analogues in biochemistry research, including CB1 receptor inverse agonists.

• Product code: B2441
• M​olecular Weight: 288.34 g/mol
• Melting Point: 88 °C – 92 °C
• Synonyms: 1-(4,4'-Difluorobenzhydryl)piperazine, 1-(4,4'-Difluorodiphenylmethyl)piperazine, 4,4'-Difluorobenzhydrylpiperazine
• Classification: Fluorinated building block, Heterocyclic building block, APIs, antimicrobials

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