1-Bromo-2-chloro-4-fluorobenzene (CAS 110407-59-5) is a polyhalogenated aromatic building block: a benzene ring carrying bromine, chlorine and fluorine substituents. Supplied by Ossila as a clear liquid with high purity (>98%), it gives chemists several reactive handles in one molecule for drug discovery, medicinal chemistry and biochemistry research.
In pharmaceutical work, this compound is a key intermediate in the route to brilanestrant, a selective estrogen receptor degrader investigated for breast cancer treatment. The building block influences potency in degrading estrogen receptor 1 (ERα), with an effective concentration of 0.7 nM reported.
It is also a starting point for a biphenyl boronic acid catalyst used in peptide synthesis. The route forms the Grignard reagent (a magnesium bromide analog), which is then treated with trimethyl borate and followed by acid hydration. The resulting catalyst has shown 97% conversion in peptide synthesis over a 4-hour reaction.
- Intermediate in the synthesis of brilanestrant, a selective estrogen receptor degrader for breast cancer research.
- Preparation of a biphenyl boronic acid catalyst for peptide synthesis via its Grignard reagent.
- Fluorinated, brominated and chlorinated building block for drug discovery and medicinal chemistry.
- Starting material for organic synthesis in biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 110407-59-5 |
| Molecular formula | C6H3BrClF |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | Clear liquid |
| Storage | — |
- Product code: B2841
- Molecular Weight: 209.44 g/mol
- Synonyms: 2-Chloro-4-fluorobromobenzene
- Classification / Family: Fluorinated building blocks, Brominated building blocks, Chlorinated building blocks, APIs, Catalysts
- Boiling Point: 193 °C – 195 °C at 760 mmHg
- Relative Density: 1.75 g/mL
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