2,2-Difluorocyclopropanecarboxylic acid (CAS 107873-03-0) is a fluorinated building block made of a three-membered carbon ring carrying two fluorine atoms on the same carbon and a carboxylic acid group. It serves as an intermediate for active pharmaceutical ingredients (APIs) and supports organic synthesis, medicinal chemistry and biochemistry research. It is supplied as an off-white powder with a purity of >97%.
Placing both fluorines on one carbon creates an inductive effect that makes this acid stronger than its non-fluorinated cyclopropane counterpart. The carboxylic acid handle lets chemists link the ring to molecular scaffolds by esterification, or convert it into an acyl halide, isocyanate or amine to access other reaction pathways.
In Friedel-Crafts reactions with arenes, the compound has shown an unexpected ring-opening. The proposed explanation is that forming the acylium ion destabilises the strained three-membered ring, causing it to open.
- Intermediate in the synthesis of active pharmaceutical ingredients.
- Introducing a gem-difluorinated cyclopropane unit into molecular scaffolds through esterification.
- Precursor for acyl halides, isocyanates and amines via functional group conversion.
- Building block for medicinal chemistry and biochemistry research.
- Studies of Friedel-Crafts and ring-opening chemistry of strained fluorinated rings.
| Brand | Ossila |
|---|---|
| CAS number | 107873-03-0 |
| Molecular formula | C4H4F2O2 |
| Purity | >97% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B2561
- Molecular Weight: 122.07 g/mol
- Synonyms: 2,2-Difluorocyclopropane-1-carboxylic Acid
- Classification / Family: Fluorinated building blocks, Carboxylic acid building blocks, APIs
- Melting Point: 60 °C – 65 °C
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