2,4,5-Trifluorophenylacetic acid (CAS 209995-38-0) is a fluorinated phenylacetic acid building block, supplied by Ossila as a white powder with >98% purity. Its benzene ring carries three fluorine atoms, and the molecule combines this fluorinated ring with a carboxylic acid group, giving it multiple functional groups for straightforward synthesis work.
In perovskite photovoltaics it serves as a bifunctional additive. The carboxylic acid binds to Pb clusters and passivates deep-energy-level defects, which raised power conversion efficiency from 22.95% to 24.56% in a reported FTO/TiO2/perovskite/Spiro-OMeTAD/Au device. The water-repelling trifluorobenzene unit also improves stability: devices kept 93.6% of their initial efficiency after 3912 hours of storage in air.
In medicinal chemistry the compound is a precursor to sitagliptin, a type-2 diabetes drug, prepared through a four-step route with an overall yield of 65%. It is offered in 2 g, 5 g, 10 g and 25 g packs.
- Bifunctional additive for passivating defects and improving the efficiency of perovskite solar cells.
- Hydrophobic additive for enhancing the air stability of perovskite devices.
- Precursor for the synthesis of the anti-diabetic drug sitagliptin.
- Fluorinated building block for drug discovery and medicinal chemistry.
| Brand | Ossila |
|---|---|
| CAS number | 209995-38-0 |
| Molecular formula | C8H5F3O2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g, 25 g |
| Physical form | White powder |
| Storage | — |
- Product code: B3441
- Full Name: (2,4,5-Trifluorophenyl)acetic acid
- Molecular Weight: 190.12 g/mol
- Synonyms: 2,4,5-Trifluorobenzeneacetic acid, 2-(2,4,5-Trifluorophenyl)acetic acid, TFPB
- Melting Point: 121 °C – 125 °C
- Classification / Family: Fluorinated building blocks, Phenylacetic acid building blocks, Perovskite solar cell additives, Solid additive, APIs
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