2,4,6-Trifluorophenylacetic acid (CAS 209991-63-9) is a fluorinated building block based on phenylacetic acid, carrying fluorine atoms at the 2-, 4- and 6-positions of the aromatic ring. Supplied as white crystals with a purity of 98%, it serves as an intermediate in the preparation of active pharmaceutical ingredients (APIs) and agricultural fungicides.
The carboxylic acid group forms amide bonds with amines when activated by N-hydroxysuccinimide and N,N'-diisopropylcarbodiimide. This coupling route has been applied to build glucosamine-based supramolecular nanotubes studied for human mesenchymal cell therapy.
In agrochemical work, the acid is reacted with phenylglyoxylic acid under basic conditions to give a furandione intermediate, which is then treated with hydrazine to yield pyridazine fungicides. Its multiple functional groups make it a practical starting point for drug discovery, medicinal chemistry and biochemistry research.
- Intermediate for the synthesis of active pharmaceutical ingredients.
- Preparation of pyridazine-based agricultural fungicides via a furandione intermediate.
- Amide coupling with amines using N-hydroxysuccinimide and N,N'-diisopropylcarbodiimide.
- Construction of glucosamine-based supramolecular nanotubes for mesenchymal cell therapy research.
- Fluorinated building block for drug discovery and medicinal chemistry.
| Brand | Ossila |
|---|---|
| CAS number | 209991-63-9 |
| Molecular formula | C8H5F3O2 |
| Purity | 98% |
| Category | — |
| Pack sizes | 250 mg, 500 mg, 1 g |
| Physical form | White crystals |
| Storage | — |
- Product code: B2881
- Molecular Weight: 190.12 g/mol
- Synonyms: 2,4,6-Trifluorobenzeneacetic acid
- Classification / Family: Fluorinated building blocks, Phenylacetic acid building blocks, APIs, Fungicides, Heterocycles
- Melting Point: 110 °C – 112 °C
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