2,4-Difluorobenzonitrile (CAS 3939-09-1) from Ossila is a fluorinated benzonitrile building block carrying fluorine atoms at the 2- and 4-positions. It is supplied as a white to off-white solid with a purity above 98%, in 25 g and 50 g packs.
Chemists use this compound to attach a fluorinated benzonitrile unit to target molecules through nucleophilic aromatic substitution. Substitution takes place mainly at the fluorine para to the nitrile group, the less sterically hindered site. Triazolopyrimidines functionalized with this group have been studied extensively as candidates for treating Alzheimer's disease.
Reaction with sodium azide converts the nitrile into a fluorinated tetrazole, a five-membered heterocycle containing four nitrogen atoms. Iridium complexes built from fluorinated phenyltetrazole ligands emit blue light with photoluminescence quantum yields of up to 76%, making them of interest for OLEDs and photoredox catalysis.
- Introducing fluorinated benzonitrile groups into target molecules by nucleophilic aromatic substitution.
- Synthesis of fluorinated tetrazole ligands via reaction with sodium azide.
- Preparation of blue-emitting iridium complexes for OLED research.
- Development of photoredox catalysts.
- Drug discovery and API synthesis, including triazolopyrimidines studied for Alzheimer's disease.
| Brand | Ossila |
|---|---|
| CAS number | 3939-09-1 |
| Molecular formula | C7H3F2N |
| Purity | >98% |
| Category | — |
| Pack sizes | 25 g, 50 g |
| Physical form | White to off-white solid |
| Storage | — |
- Product code: B2251
- Molecular Weight: 139.10 g/mol
- Melting Point: 47 – 49 °C
- Classification / Family: Fluorinated building block, Ligands, OLEDs, APIs, Photoredox catalysts
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