2-Amino-3-fluoropyridine (CAS 21717-95-3, also known as 3-fluoro-2-pyridinamine) is a fluorinated heterocyclic building block based on pyridine, carrying an amine group at the 2-position and a fluorine atom at the 3-position. It is supplied as a white powder or chunks with a purity above 98%, for use in medicinal chemistry, drug discovery and biochemistry research.
Thanks to its multiple functional groups, this compound can be attached to molecular scaffolds through reductive amination or nucleophilic substitution, offering a straightforward way to add a fluorinated pyridine unit. Molecules modified with this moiety have shown markedly stronger antitumor activity than their parent structures, an effect attributed to a π–π interaction between the fluoropyridine ring and an arginine residue in the target protein.
It also serves as a precursor for bicyclic heterocycles, such as imidazopyridines prepared via the Baylis-Hillman reaction, which are relevant to pharmaceutical active ingredients.
- Introducing a fluorinated pyridine moiety into molecular scaffolds by reductive amination or nucleophilic substitution.
- Synthesis of imidazopyridines and other bicyclic heterocycles via the Baylis-Hillman reaction.
- Preparation of candidate pharmaceutical active ingredients in drug discovery programmes.
- Structural modification of compounds in antitumor medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 21717-95-3 |
| Molecular formula | C5H5FN2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g |
| Physical form | White powder/chunks |
| Storage | — |
- Product code: B2601
- Molecular Weight: 112.11 g/mol
- Synonyms: 3-Fluoro-2-pyridinamine
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, APIs, Bicyclic heterocycles
- Melting Point: 41 °C – 45 °C
—
—