2-Amino-5-chloro-3-fluoropyridine (CAS 246847-98-3) is a fluorinated aminopyridine building block used in drug discovery, medicinal chemistry and the preparation of metal complexes. The pyridine ring carries an amine group at the 2-position, fluorine at the 3-position and chlorine at the 5-position, giving several functional handles for straightforward synthesis.
In coordination chemistry, the pyridinium amine binds readily to copper centres in neutral or acidic media. The copper complexes formed in this way show antiferromagnetic interactions in the range of −0.9 to −31.3 K.
In pharmaceutical research, the compound serves as an intermediate for active pharmaceutical ingredients (APIs), including cyclin-dependent kinase inhibitors investigated for cancer treatment and disruptors of glucokinase-glucokinase regulatory protein binding aimed at type II diabetes mellitus. It is supplied as a beige powder with a purity of >97%.
- Synthesis of cyclin-dependent kinase inhibitors for cancer treatment research.
- Preparation of glucokinase-glucokinase regulatory protein disruptors for type II diabetes mellitus research.
- Formation of copper complexes for studies of antiferromagnetic interactions.
- General use as a fluorinated heterocyclic building block in medicinal chemistry and drug discovery.
| Brand | Ossila |
|---|---|
| CAS number | 246847-98-3 |
| Molecular formula | C5H4ClFN2 |
| Purity | >97% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g, 50 g |
| Physical form | Beige powder |
| Storage | — |
- Product code: B3391
- Full Name: 5-Chloro-3-fluoro-2-pyridinamine
- Molecular Weight: 146.55 g/mol
- Synonyms: 5-Chloro-3-fluoropyridin-2-amine, 5-chloro-3-fluoro-2-pyridylamine
- Melting Point: 91 °C – 95 °C
- Classification / Family: Fluorinated building blocks, Heterocyclic building blocks, Pyridine building blocks, Amine building blocks, Organometallic complexes, APIs
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