Ossila 2-Amino-5-fluorobenzonitrile B2711

2-Amino-5-fluorobenzonitrile (CAS 61272-77-3) from Ossila is a fluorinated ortho-aminobenzonitrile supplied as a grey powder with a purity above 97%. It is a compact building block that combines an amine, a nitrile and a fluorine substituent on one benzene ring, making it useful for medicinal chemistry, organometallic catalysis and biochemistry research.

Because the amine and nitrile groups sit next to each other on the ring, the compound is well suited to ring-forming reactions that produce heterocycles. With aminoethanol derivatives under zinc chloride catalysis it gives oxazoline ligands used in Cu-catalyzed enantioselective nitroaldol reactions. In a Friedländer reaction with cyclic ketones it leads to tacrine derivatives, and under basic conditions its reaction with cyclic ketone derivatives provides routes to quinazoline and quinazolinone derivatives.

The material has a molecular weight of 136.13 g/mol and melts between 92 °C and 96 °C. It is available in 5 g and 10 g packs.

• Preparation of oxazoline ligands for Cu-catalyzed enantioselective nitroaldol reactions.
• Synthesis of tacrine derivatives through Friedländer reactions with cyclic ketones.
• Construction of quinazoline and quinazolinone derivatives under basic conditions.
• Use as a fluorinated aniline and benzonitrile building block in medicinal chemistry and API research.

• Product code: B2711
• M​olecular Weight: 136.13 g/mol
• Melting Point: 92 °C – 96 °C
• Synonyms: 2-Amino-5-fluorobenzenecarbonitrile, 2-Cyano-4-fluoroaniline
• Classification / Family: Fluorinated building blocks, Aniline building blocks, Benzonitrile building blocks, APIs, Heterocycles, Ligands

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