2-Amino-6-fluorobenzonitrile (CAS 77326-36-4) from Ossila is a fluorinated benzonitrile and aniline building block supplied as an off-white powder with a purity above 98%. Its structure combines three reactive handles, a fluoride, a nitrile and an amine, which makes it a versatile intermediate for drug discovery, medicinal chemistry and biochemistry research.
Because the amine and nitrile groups sit next to each other in the ortho position, the compound is well suited to building quinazolines. These bicyclic heterocycles form the core of antimalarial and anticancer agents, including Gefitinib, Lapatinib, Erlotinib and Afatinib.
Reaction with ketones gives access to aminoquinoline derivatives, a route that can be used to prepare tacrine derivatives, which act as cholinesterase inhibitors studied for Alzheimer's disease. The product is offered in 25 g and 50 g packs.
- Precursor for synthesizing quinazoline derivatives used in antimalarial and anticancer research.
- Starting material for aminoquinoline derivatives through reaction with ketones.
- Preparation of tacrine derivatives as cholinesterase inhibitors for Alzheimer's disease research.
- Fluorinated building block for drug discovery and medicinal chemistry programmes.
| Brand | Ossila |
|---|---|
| CAS number | 77326-36-4 |
| Molecular formula | C7H5FN2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 25 g, 50 g |
| Physical form | Off-white powder |
| Storage | — |
- Product code: B2651
- Molecular Weight: 136.13 g/mol
- Synonyms: 2-Cyano-3-fluoroaniline, 6-Fluoro-2-aminobenzonitrile
- Classification / Family: Fluorinated building blocks, Aniline building blocks, APIs, Heterocycles
- Melting Point: 127 °C – 131 °C
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