2-Bromo-3′-fluoroacetophenone (CAS 53631-18-8), also called 3-fluorophenacyl bromide, is a dihalogenated acetophenone building block from Ossila. Its benzene ring carries a fluorine atom, while a bromine sits on the α-carbon of the ketone, giving chemists several reactive sites for straightforward synthesis of heterocycles and ligands.
A common route uses this compound to prepare thiazoles: refluxing it with thiourea in ethanol gives thiazolyl products. Such derivatives have been studied as correctors of the chloride transport defect in cystic fibrosis, as glutathione S-transferase Omega 1 inhibitors and as agents against Trypanosoma brucei.
Reaction with ortho-phenylenediamine derivatives instead yields pyrazines. When built into iridium complexes, these pyrazine ligands give phosphorescence ranging from yellow to deep red (λem = 579 – 655 nm). The material is supplied as white crystals with a purity of >97%.
- Synthesis of thiazole derivatives through reaction with thiourea in refluxing ethanol.
- Preparation of pyrazine derivatives from ortho-phenylenediamine derivatives.
- Building ligands for phosphorescent iridium complexes emitting yellow to deep red light.
- Medicinal chemistry research on glutathione S-transferase Omega 1 inhibitors and cystic fibrosis chloride transport correctors.
- Biochemistry research on compounds active against Trypanosoma brucei.
| Brand | Ossila |
|---|---|
| CAS number | 53631-18-8 |
| Molecular formula | C8H6BrFO |
| Purity | >97% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | White crystals |
| Storage | — |
- Product code: B2501
- Full Name: 2-Bromo-1-(3-fluorophenyl)ethan-1-one
- Molecular Weight: 217.04 g/mol
- Synonyms: 3-Fluorophenacyl bromide, 2-Bromo-1-(3-fluorophenyl)ethanone
- Classification / Family: Fluorinated building blocks, Heterocycles, Phosphorescent complexes, APIs
- Melting Point: Tm = 33 °C – 37 °C
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