2-Bromo-4-fluorobenzonitrile (CAS 36282-26-5, C7H3BrFN) is a dihalogenated benzonitrile building block for drug discovery, medicinal chemistry and synthetic research. Bromine sits at the ortho position and fluorine at the para position relative to the nitrile, giving the molecule three distinct reactive handles.
Each group can be addressed separately. The bromo substituent takes part in palladium-catalysed C-C coupling, while the fluoride serves as a good leaving group in nucleophilic aromatic substitution. The nitrile activates the ring towards that substitution and can also react with hydroxylamine to give oxadiazoles, a class whose derivatives act on type 2 cannabinoid receptors and are studied for central nervous system disorders.
The compound is supplied as a pale purple powder with a melting point of 77 °C and a molecular weight of 200.01 g/mol.
- Serves as a molecular scaffold for synthesising active pharmaceutical ingredients (APIs).
- Acts as a substrate for Pd-catalysed C-C coupling through its bromo substituent.
- Undergoes nucleophilic aromatic substitution at the fluoride position.
- Converts to oxadiazole derivatives via reaction of the nitrile with hydroxylamine, relevant to CB2 receptor research.
- Introduces reactive functional groups onto other molecular scaffolds in synthetic chemistry.
| Brand | Ossila |
|---|---|
| CAS number | 36282-26-5 |
| Molecular formula | C7H3BrFN |
| Purity | 97% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | Pale purple powder |
| Storage | — |
- Product code: B2621
- Molecular Weight: 200.01 g/mol
- Synonyms: 4-Fluoro-2-bromobenzonitrile
- Classification / Family: Fluorinated building blocks, Benzonitrile building blocks, Heterocycles, APIs
- Melting Point: Tm = 77 °C
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