2-Bromo-6-fluorobenzaldehyde (CAS 360575-28-6) from Ossila is a fluorinated benzaldehyde building block carrying bromine and fluorine substituents at the two ortho positions. With several reactive functional groups on one ring, it serves as a versatile starting material for ligands, bicyclic heterocycles and semiconducting materials. It is supplied as a beige powder with a purity of 97% and a melting point of 43 – 47 °C.
In organic synthesis, the compound is the precursor to fluoro-2-formylphenyl boronic acid, a probe for 1H and 19F NMR that measures the enantiopurity of sulfinamides, which are common chiral auxiliaries in asymmetric synthesis. It also reacts with primary amines and sodium azide under copper(II) oxide catalysis to give indazoles and related bicyclic heterocycles.
In materials research, halogenated benzaldehydes of this type can guide macromolecular self-assembly into nanostructures. A thienoisoindigo-based semiconducting nanowire assembled with 2-bromobenzaldehyde through halogen and chalcogen bonding showed a hole mobility of 6.39×10−4 cm2/Vs.
- Synthesis of fluoro-2-formylphenyl boronic acid, a 1H and 19F NMR probe for determining sulfinamide enantiopurity.
- Copper(II) oxide-catalyzed preparation of indazoles and other bicyclic heterocycles with primary amines and sodium azide.
- Building block for ligand synthesis.
- Directing self-assembly of macromolecules into semiconducting nanostructures.
- Fluorinated intermediate for drug discovery research.
| Brand | Ossila |
|---|---|
| CAS number | 360575-28-6 |
| Molecular formula | C7H4BrFO |
| Purity | 97% |
| Category | — |
| Pack sizes | 5 g, 10 g, 25 g |
| Physical form | Beige powder |
| Storage | — |
- Product code: B2381
- Molecular Weight: 203.01 g/mol
- Synonyms: 6-Bromo-2-fluorobenzaldehyde, 2-Fluoro-6-bromobenzaldehyde
- Melting Point: 43 – 47 °C
- Classification / Family: Fluorinated building blocks, Benzaldehyde building block, Ligands, NMR probes, Semiconductors
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