2-Chloro-5-fluoronitrobenzene (CAS 345-17-5), also known as 1-chloro-4-fluoro-2-nitrobenzene, is a substituted benzene carrying chloro, fluoro and nitro groups on a single ring. Ossila supplies it at >98% purity as off-white crystals for drug discovery, medicinal chemistry and biochemistry work.
Its main role is as an intermediate in the preparation of active pharmaceutical ingredients (APIs). A notable route uses it together with methylacetophenone and elemental sulfur to build benzothiazole derivatives. It is also a starting material for fluorophenylthio-benzylamine compounds that bind serotonin transporters (SERT), showing high selectivity for SERT over norepinephrine and dopamine transporters.
With several reactive functional groups on one aromatic core, the compound gives chemists flexible options for straightforward synthetic modification. It is offered in 2 g, 5 g, 10 g and 25 g packs.
- Intermediate in the synthesis of active pharmaceutical ingredients (APIs).
- Reagent for preparing benzothiazole derivatives with methylacetophenone and elemental sulfur.
- Precursor for fluorophenylthio-benzylamine ligands that bind serotonin transporters (SERT).
- Fluorinated and chlorinated building block for drug discovery and medicinal chemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 345-17-5 |
| Molecular formula | C6H3ClFNO2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g, 25 g |
| Physical form | Off-White Crystals |
| Storage | — |
- Product code: B3251
- Full Name: 1-Chloro-4-fluoro-2-nitrobenzene
- Synonyms: 1-Chloro-4-fluoronitrobenzene
- Molecular Weight: 175.54 g/mol
- Melting Point: 37 °C – 39 °C
- Classification / Family: Fluorinated building blocks, Chlorinated building blocks, APIs, Benzothiazoles
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