2-Chloro-5-fluoropyrimidine (CAS 62802-42-0), also known as 5-fluoro-2-chloropyrimidine, is a fluorinated heterocyclic building block supplied as a colorless liquid with a purity of >98%. It serves as a synthesis intermediate in drug discovery and in the preparation of organometallic ligands and semiconducting materials for OLEDs.
The molecule is based on pyrimidine, a six-membered aromatic ring carrying nitrogen atoms at positions 1 and 3. Chlorine and fluorine substituents sit para to each other, which makes the compound well suited to building linear molecules. Because the two ring nitrogens leave the system π electron deficient, the ring readily undergoes nucleophilic aromatic substitution.
In pharmaceutical chemistry it is a common starting point for active pharmaceutical ingredients such as antibiotics. In materials research it is used to prepare ligands for iridium complexes, which have shown external quantum efficiency exceeding 29.5%.
- Synthesis of active pharmaceutical ingredients (APIs), including antibiotics.
- Building block for drug discovery programmes based on pyrimidine scaffolds.
- Preparation of ligands for iridium complexes used in OLED emitters.
- Construction of linear molecules through nucleophilic aromatic substitution.
- Intermediate for semiconducting materials research.
| Brand | Ossila |
|---|---|
| CAS number | 62802-42-0 |
| Molecular formula | C4H2ClFN2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | Colorless liquid |
| Storage | — |
- Product code: B2391
- Molecular Weight: 132.52 g/mol
- Synonyms: 5-Fluoro-2-chloropyrimidine
- Classification / Family: Fluorinated building block, Heterocyclic building block, APIs, OLEDs
- Boiling Point: 172 – 174 °C at 760 mmHg
- Relative Density: 1.073 g/mL at 25 °C
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