2-Fluoro-4-hydroxybenzoic acid (CAS 65145-13-3) from Ossila is a fluorinated benzoic acid building block supplied as a white powder with >98% purity. It serves as an intermediate in the synthesis of liquid crystals and active pharmaceutical ingredients (APIs).
Structurally, it is a para-hydroxybenzoic acid with a fluorine atom at the ortho position. Having the carboxylic acid and hydroxy groups para to each other makes the molecule well suited to building mesogens for liquid crystals. A long alkyl tail can be attached easily using an alkyl bromide under basic conditions, while the ortho fluorine gives rise to an additional intercalated smectic phase.
The compound is also used in cancer immunotherapy research to prepare a polyphosphazene immunoadjuvant. In this route, hexachlorocyclotriphosphazene undergoes ring-opening polymerization, after which the deprotonated phenoxide of 2-fluoro-4-hydroxybenzoic acid substitutes onto the polymer by nucleophilic substitution. The product is offered in 10 g and 25 g pack sizes.
- Synthesis of mesogens for liquid crystals, including phases with an additional intercalated smectic phase.
- Intermediate for the synthesis of active pharmaceutical ingredients (APIs).
- Preparation of fluorine-functionalized polyphosphazene immunoadjuvants for cancer immunotherapy research.
- Building block for drug discovery and biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 65145-13-3 |
| Molecular formula | C7H5FO3 |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2751
- Molecular Weight: 156.11 g/mol
- Synonyms: 4-Hydroxy-2-fluorobenzoic acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, Liquid crystals, APIs
- Melting Point: 200 °C – 202 °C
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