2-Fluoro-4-nitroaniline (CAS 369-35-7), also known as 2-fluoro-4-nitrobenzenamine, is a fluorinated aniline building block supplied by Ossila as a brown powder with 97% purity. The molecule carries a fluorine atom at the 2-position and a nitro group at the 4-position of the aniline ring, giving chemists several reactive sites to work with.
Its amine group takes part in nucleophilic substitution and diazotization, while the nitro group can later be reduced to a second amine for further transformations. This makes it a flexible scaffold for building active pharmaceutical ingredients; for example, it is the starting material for a key intermediate of the antibiotic candidate TBI-223.
Beyond drug synthesis, the compound has been applied in materials research. It has been used to create sp3 defects on semiconducting single-walled carbon nanotubes (SWCNTs) to produce organic color center-tailored nanotubes, and to prepare a lithium bismaleamate anode material for Li-ion batteries with an electrode capacity of 688.9 mAhg−1.
- Intermediate for the synthesis of active pharmaceutical ingredients (APIs).
- Preparation of a key intermediate for the antibiotic drug candidate TBI-223.
- Introduction of sp3 defects onto semiconducting SWCNTs for color center-tailored carbon nanotubes.
- Synthesis of lithium bismaleamate organic anode materials for Li-ion batteries.
| Brand | Ossila |
|---|---|
| CAS number | 369-35-7 |
| Molecular formula | C6H5FN2O2 |
| Purity | 97% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g |
| Physical form | Brown powder |
| Storage | — |
- Product code: B2671
- Molecular Weight: 156.11 g/mol
- Synonyms: 2-Fluoro-4-nitrobenzenamine
- Melting Point: 122 °C – 130 °C
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