2-Fluoro-4-(trifluoromethyl)aniline (CAS 69409-98-9) is a fluorinated aniline building block with a purity of 98%, supplied as a colorless liquid. The aniline ring carries a fluorine atom at the 2-position and a trifluoromethyl group at the 4-position, giving several functional groups for straightforward synthesis in drug discovery, medicinal chemistry and biochemistry research.
Because the fluorine sits ortho to the amine, it can undergo nucleophilic aromatic substitution. This makes the compound a useful starting point for bicyclic heterocycles such as quinoxalines and quinoline, and for tricyclic systems including benzoimidazotriazines, phenazines and phenoxazines.
The compound also serves as an intermediate for phenylacetamides and for ocfentanil derivatives studied as analgesics. Through conjugated addition to para-quinone methides, it gives access to triarylmethane derivatives relevant to APIs and dyes.
- Synthesis of bicyclic heterocycles such as quinoxalines and quinoline via nucleophilic aromatic substitution.
- Preparation of tricyclic heterocycles including benzoimidazotriazines, phenazines and phenoxazines.
- Building block for ocfentanil derivatives investigated as analgesics.
- Synthesis of triarylmethane derivatives by conjugated addition to para-quinone methides.
- Intermediate for phenylacetamides used in API and dye research.
| Brand | Ossila |
|---|---|
| CAS number | 69409-98-9 |
| Molecular formula | C7H5F4N |
| Purity | 98% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | Colorless liquid |
| Storage | — |
- Product code: B2531
- Molecular Weight: 179.11 g/mol
- Synonyms: 4-Amino-3-fluorobenzotrifluoride, 2-Fluoro-4-(trifluoromethyl)benzenamine
- Classification / Family: Fluorinated building block, Heterocycles, Triarylmethanes, APIs
- Boiling Point: 55 °C at 0.3 mmHg
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