2-Fluoro-4-(trifluoromethyl)benzoic acid (CAS 115029-24-8) is a polyfluorinated benzoic acid carrying a fluoride group at the 2-position and a trifluoromethyl group at the 4-position. Supplied by Ossila as a white powder with >98% purity, it serves as a synthetic building block for drug discovery, medicinal chemistry and biochemistry research.
Its carboxylic acid group allows straightforward coupling to molecular scaffolds by condensation reactions, and it can be converted through functional group exchange into acyl chlorides, aldehydes and anhydrides.
Structure-activity relationship work has shown that the fluoride and trifluoromethyl groups introduced by this compound enhance the agonistic activity of G protein-coupled receptors. This higher potency is attributed to halogen bonding between the fluorinated groups and proteins, making the acid a useful precursor for active pharmaceutical ingredients (APIs).
- Precursor for synthesising APIs with improved receptor agonist activity.
- Introducing fluoride and trifluoromethyl groups into G protein-coupled receptor agonist candidates.
- Attaching a fluorinated benzoyl unit to molecular scaffolds through condensation reactions.
- Preparing acyl chlorides, aldehydes and anhydrides via functional group exchange.
- Building block for drug discovery, medicinal chemistry and biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 115029-24-8 |
| Molecular formula | C8H4F4O2 |
| Purity | >98% |
| Category | — |
| Pack sizes | 5 g, 10 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2831
- Molecular Weight: 208.11 g/mol
- Synonyms: α,α,α,2-Tetrafluoro-p-toluic acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, APIs
- Melting Point: 168 °C – 170 °C
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