Ossila 2-Fluoro-5-nitrobenzoic acid B2451

2-Fluoro-5-nitrobenzoic acid (CAS 7304-32-7) from Ossila is a fluorinated nitrobenzoic acid building block supplied as a white powder with a purity of >98%. Its benzoic acid core carries a fluorine atom at the 2-position and a nitro group at the 5-position, giving chemists several reactive handles in one small molecule for drug discovery, bioimaging and peptide research.

A key use is the preparation of fluorescent sensing molecules. Esterifying this acid with fluorescent dyes produces probes that glow only weakly on their own. When target nucleophiles such as hydrazine or endogenous hydrogen polysulfide are present, they cleave the ester bond, freeing the strongly fluorescent dye so that the signal can be followed by fluorescence microscopy, including in living cells.

Because the fluorine sits right next to the carboxylic acid group, the compound is also well suited to building polycyclic heterocycles and β-turn cyclic peptidomimetics. Published work describes its use in solid-phase synthesis of 2,1,3-benzothiadiazin-4-one 2-oxides and in one-pot, high-throughput routes to cyclic peptidomimetics. The material is offered in 10 g, 25 g and 50 g pack sizes.

• Synthesis of turn-on fluorescent probes for hydrazine and endogenous hydrogen polysulfide through esterification with fluorescent dyes.
• Preparation of polycyclic heterocycles for heterocyclic API research.
• Construction of β-turn cyclic peptidomimetics for peptide research.
• Solid-phase synthesis of 2,1,3-benzothiadiazin-4-one 2-oxides.
• Use as a multifunctional fluorinated building block in drug discovery and bioimaging.

• Product code: B2451
• M​olecular Weight: 185.11 g/mol
• Synonyms: 2-Fluoro-5-nitrobenzenecarboxylate
• Melting Point: 142 °C – 144 °C
• Classification / Family: Fluorinated building block, fluorescent probes, Heterocyclics, APIs, Peptides

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