2-Fluoro-6-methylbenzoic acid (CAS 90259-27-1) is a fluorinated benzoic acid building block for medicinal chemistry, drug discovery and biochemistry. Its structure carries a fluorine atom and a methyl group, both positioned ortho to the carboxylic acid, giving chemists several reactive handles in one small molecule. It is supplied as a white powder with a purity of 97%.
The compound serves as an intermediate in the preparation of active pharmaceutical ingredients. In one reported route to an EGFR inhibitor with a potency of 340 nM, the methyl group is first brominated by a radical process, allowing nucleophilic substitution with phthalimide; the carboxylic acid is then coupled to an allosteric motif by amination to complete the inhibitor.
It is also a key building block in the synthesis of avacopan, a drug used in the treatment of anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
- Synthesis intermediate for active pharmaceutical ingredients (APIs).
- Preparation of epidermal growth factor receptor (EGFR) inhibitors via radical bromination and amination steps.
- Building block in the synthesis of avacopan for ANCA-associated vasculitis treatment.
- Fluorinated building block for drug discovery, medicinal chemistry and biochemistry research.
| Brand | Ossila |
|---|---|
| CAS number | 90259-27-1 |
| Molecular formula | C8H7FO2 |
| Purity | 97% |
| Category | — |
| Pack sizes | 2 g, 5 g, 10 g |
| Physical form | White Powder |
| Storage | — |
- Product code: B3331
- Molecular Weight: 154.14 g/mol
- Synonyms: 2-Carboxy-3-fluorotoluene, 6-Fluoro-o-toluic acid
- Classification / Family: Fluorinated building blocks, Benzoic acid building blocks, APIs
- Melting Point: 124 °C – 125 °C
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