2-Fluoroadenine (CAS 700-49-2) is a fluorinated form of adenine, the purine nucleobase found in DNA. Its structure combines fused pyrimidine and imidazole rings, and it is supplied by Ossila as a white powder with a purity of >97%, intended as a fluorinated and heterocyclic building block for synthesis and drug discovery.
In cancer research, 2-fluoroadenine has been studied as a radiosensitizer: under low energy electron (20 eV) radiation it contributes to DNA damage in cancer cells. The fluorine atom also makes it useful as a 19F NMR probe, and it has been applied to follow conformational exchange in the neomycin-sensing riboswitch.
Adenine-based chemistry extends to soft materials as well. A thermoreversible hydrogel formed in water from adenine and 1,3,5-tris(4-carboxyphenyl)benzene can take up dyes such as methylene blue, rhodamine 6G and crystal violet, pointing to water purification uses. The compound is available in 1 g, 2 g and 5 g packs.
- Radiosensitizer research in which DNA in cancer cells is damaged under low energy electron (20 eV) radiation.
- Fluorine probe for 19F NMR studies of nucleic acid conformational exchange, such as in the neomycin-sensing riboswitch.
- Fluorinated heterocyclic building block for drug discovery and API synthesis.
- Research on adenine-based hydrogels for capturing dyes in water purification.
| Brand | Ossila |
|---|---|
| CAS number | 700-49-2 |
| Molecular formula | C5H4FN5 |
| Purity | >97% |
| Category | — |
| Pack sizes | 1 g, 2 g, 5 g |
| Physical form | White powder |
| Storage | — |
- Product code: B2291
- Molecular Weight: 153.12 g/mol
- Synonyms: 2-Fluoro-7H-purin-6-amine, 2-Fluoro-6-aminopurine
- Melting Point: Tm > 350 °C
- Classification: Fluorinated building block, Heterocyclic building block, APIs, Radiosensitizers, Hydrogels
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