2-Fluorobiphenyl (CAS 321-60-8) from Ossila is a biphenyl carrying a single fluorine atom in the ortho position. Supplied as white crystals with a purity above 98%, it is a versatile fluorinated building block for drug discovery, ligand work and materials chemistry.
In pharmaceutical chemistry it serves as an intermediate for active pharmaceutical ingredients; the 2-fluorobiphenyl unit forms part of the structure of flurbiprofen, a nonsteroidal anti-inflammatory drug. Synthetic chemists also use it in arylation reactions, and its fluorine atom makes it useful as a 19F NMR probe for working out molecular structures.
For materials research, 2-fluorobiphenyl can be converted by Friedel-Crafts acylation into microporous organic polymers (MOPs) with a surface area of 917 m2/g. These polymers have been studied for separating xenon from krypton and for encapsulating phase change materials used in thermal energy storage.
- Intermediate in the synthesis of active pharmaceutical ingredients such as flurbiprofen-related structures.
- Substrate for arylation reactions in organic synthesis.
- 19F NMR probe to assist in determining molecular structures.
- Monomer for microporous organic polymers prepared by Friedel-Crafts acylation.
- Preparation of porous polymers for xenon/krypton gas separation.
- Preparation of polymers that encapsulate phase change materials for thermal energy storage.
| Brand | Ossila |
|---|---|
| CAS number | 321-60-8 |
| Molecular formula | C12H9F |
| Purity | >98% |
| Category | — |
| Pack sizes | 10 g, 25 g, 50 g, 100 g |
| Physical form | White crystals |
| Storage | — |
- Product code: B3461
- Molecular Weight: 172.20 g/mol
- Synonyms: 1-Fluoro-2-phenyl-benzene, 2-Fluoro-1,1'-biphenyl
- Melting Point: 71 °C – 74 °C
- Classification / Family: Fluorinated building blocks, Biphenyl building blocks, Ligands, MOPs, NMR probes, APIs
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